Evidence map›Paper›PMID 41614072›Full record

ArticleFrontiers in pharmacology2025

Piperine-loaded solid lipid nanoparticles: a promising nano-phytomedicine for the treatment of non-alcoholic fatty liver disease.

Afrasim Moin, Shwetha Ram, Sateesha Shivally Boregowda, Talib Hussain, Amr Selim Abu Lila, Rajamma Abburu Jayaramu, Syed Mohd Danish Rizvi, Sirajudheen Anwar, Kalegowda Chandan

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In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Afrasim MoinDepartment of Pharmaceutics, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Shwetha RamDepartment of Pharmaceutics, Acharya & BM Reddy College of Pharmacy, Bengaluru, India.
Sateesha Shivally BoregowdaDepartment of Pharmaceutics, Acharya & BM Reddy College of Pharmacy, Bengaluru, India.
Talib HussainDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Amr Selim Abu LilaDepartment of Pharmaceutics, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Rajamma Abburu JayaramuDepartment of Pharmacognosy, KLE College of Pharmacy, Bengaluru, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.
Syed Mohd Danish RizviDepartment of Pharmaceutics, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Sirajudheen AnwarDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Kalegowda ChandanDepartment of Postharvest Management, University of Horticultural Sciences, Bagalkot, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Piperine (PIP), the active alkaloid found in black pepper ( Methods: Herein, PIP-SLNs were prepared by the hot homogenization method. The fabricated PIP-SLNs were characterized for size, zeta potential, surface morphology, entrapment efficiency and Results and discussion: Particle size, zeta potential, and drug entrapment efficiency of the optimized formula (F6) was found to be 191.2 ± 27.9 nm, - 20 ± 1.3 mV, 72.3% ± 2.8, respectively. Morphologically, the PIP-SLNs were found to be spherical. The optimized formulation (F6) exhibited sustained release up to 70% at 48 h, fitting the Higuchi model (R

Indexed as

liver enzymesnon-alcoholic fatty liver diseaseoral glucose tolerance testpiperinesolid lipid nanoparticles

Identifiers

PMID41614072
PMCPMC12847354

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.