Observational studyEuropean stroke journal2026
Are lacunar infarcts associated with a "susceptibility vessel sign"? A 7-tesla magnetic resonance imaging study.
Observational study in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Evaluation of an open-face 8-channel transmit 64-channel receive 7T head coil for neuroimaging.Frontiers in neuroscience · 2026Article
Corrections and comments
- Erratum issuedCorrection to.2026
Authors and funding
6 authors.
Funding
Abstract
introductionThe pathophysiological basis for lacunar stroke is uncertain. The susceptibility vessel sign (SVS) on magnetic resonance imaging (MRI) is associated with thrombotic large vessel occlusion and has been reported in association with lacunar infarcts using T2* imaging. We investigated the presence of a relevant SVS in acute lacunar stroke with susceptibility-weighted imaging (SWI) and time-of-flight MR angiography (TOF-MRA) at 7 Tesla (T). PATIENTS AND
methodsWe performed a single-centre prospective observational study in patients with small subcortical infarct confirmed on 1.5 or 3 T MRI. Additional 7 T MRI was acquired and raters independently reviewed 7 T SWI and TOF-MRA sequences blinded to clinical data. Presence of an SVS and any associated occluded vessels were recorded. A SVS was considered present if reported by two or more raters in the relevant hemisphere with agreement confirmed at consensus review.
resultsTwenty people (10 male, 10 female), with median age 67.5 [interquartile range (IQR) 64-81] years and median National Institutes of Health Stroke Scale 3 (IQR 2-4.75), underwent 7 T MRI. Possible SVS was visualized in 7 of 20 scans (35%) on SWI, with 4 considered highly likely (20%). TOF-MRA review showed an occluded small vessel proximal to the infarct in 1 of 20 patients (5%). This was not associated with a positive SVS on SWI.
conclusionA possible SVS was observed in up to 7 of 20 (35%) people with recent small subcortical infarcts, but anatomically related vessel occlusion was not confirmed using TOF-MRA. Diagnosis of small vessel SVS appears subjective and confirmation with 3-dimensional vascular imaging may increase reliability.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.