Evidence map›Paper›PMID 41614520›Full record

Observational studyEuropean stroke journal2026

Safety of endovascular therapy in ischemic stroke patients ⩾90 years: A cohort study from the EVA-TRISP collaboration.

Jasmine Jost, Lukas Enz, Martina B Goeldlin, Philipp Baumgartner, Davide Strambo, Nabila Wali, Nicolas Martinez-Majander, Georg Kägi, Laura Vandelli, Christoph Riegler and 38 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Jasmine JostStroke Center and Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0009-0009-2964-0814
Lukas EnzStroke Center and Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0002-6588-2142
Martina B GoeldlinDepartment of Neurology and University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.ORCID 0000-0001-5800-116X
Philipp BaumgartnerDepartment of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Davide StramboStroke Center, Neurology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Nabila WaliDepartment of Neurology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.ORCID 0009-0000-5410-7805
Nicolas Martinez-MajanderNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-8489-7051
Georg KägiDepartment of Neurology and University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Laura VandelliNeurology - Stroke Unit, Department of Neuroscience, Ospedale Civile di Baggiovara, Modena University Hospital, Modena, Italy.
Christoph RieglerDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-2478-3500
Danna KrupkaDepartment of Neurology, Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.
Matteo PaolucciIRCCS Istituto delle Scienze Neurologiche di Bologna, Department of Neurology and Stroke Center, Maggiore Hospital, Bologna, Italy.ORCID 0000-0002-5347-378X
Mauro MagoniStroke Unit and Department of Neuroradiology, ASST Spedali Civili, Brescia, Italy.
Giovanni BiancoStroke Center EOC, Neurology, Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland.
Hamza JubranDepartment of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.ORCID 0009-0009-8228-1347
Dejana R JovanovicUniversity of Belgrade, Faculty of Medicine, Neurology Clinic, University Clinical Centre of Serbia, Belgrade, Serbia.
Tomas KlailDepartment of Neurology and University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Laura P WestphalDepartment of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Alexander SalernoStroke Center, Neurology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-8494-5527
Leon A RinkelDepartment of Neurology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-0291-8515
Laura MannismäkiNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-3696-7219
Tolga DittrichDepartment of Neurology and Stroke Center, University Teaching and Research Hospital, Kantonsspital St. Gallen, St. Gallen, Switzerland.ORCID 0000-0002-9987-3631
Livio PicchettoNeurology - Stroke Unit, Department of Neuroscience, Ospedale Civile di Baggiovara, Modena University Hospital, Modena, Italy.
Regina von RennenbergDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-3444-2045
Miguel SerôdioDepartment of Neurology, Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.
Stefano ForlivesiIRCCS Istituto delle Scienze Neurologiche di Bologna, Department of Neurology and Stroke Center, Maggiore Hospital, Bologna, Italy.
Dikran MardighianStroke Unit and Department of Neuroradiology, ASST Spedali Civili, Brescia, Italy.
Carlo W CeredaStroke Center EOC, Neurology, Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland.
Ronen R LekerDepartment of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.ORCID 0000-0003-4794-0334
Visnja PadjenUniversity of Belgrade, Faculty of Medicine, Neurology Clinic, University Clinical Centre of Serbia, Belgrade, Serbia.ORCID 0000-0002-6126-8305
Mira KatanStroke Center and Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Marios-Nikos PsychogiosDepartment of Neuroradiology, University Hospital Basel, Basel, Switzerland.
Urs FischerDepartment of Neurology and University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.ORCID 0000-0003-0521-4051
Tomas DobrockyDepartment of Neurology and University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Mirjam R HeldnerDepartment of Neurology and University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Patrik MichelStroke Center, Neurology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Paul J NederkoornDepartment of Neurology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Sami CurtzeNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Gian Marco De MarchisStroke Center and Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Guido BigliardiNeurology - Stroke Unit, Department of Neuroscience, Ospedale Civile di Baggiovara, Modena University Hospital, Modena, Italy.
Christian H NolteDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-5577-1775
João Pedro MartoDepartment of Neurology, Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.ORCID 0000-0003-2277-5950
Andrea ZiniIRCCS Istituto delle Scienze Neurologiche di Bologna, Department of Neurology and Stroke Center, Maggiore Hospital, Bologna, Italy.
Alessandro PezziniDepartment of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.
Susanne WegenerDepartment of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID 0000-0003-4369-7023
Marcel ArnoldDepartment of Neurology and University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Stefan T EngelterStroke Center and Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0003-3855-6234
Henrik GensickeStroke Center and Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionData on safety of endovascular therapy (EVT) in the very elderly are scarce. Using data from a large prospective EVT registry, we aimed at providing better evidence for EVT decision-making in patients aged 90 years and older. PATIENTS AND

methodsIn this multicentre observational study from the EVA-TRISP collaboration outcomes were compared between patients aged ⩾90 years with those aged <90 years using multivariate logistic regression analysis and reporting odds ratios and 95% confidence intervals. Outcomes were occurrence of poor functional outcome in survivors (modified Rankin Scale (mRS) 3-5 if pre-stroke mRS 0-2 and mRS higher than pre-stroke mRS if pre-stroke mRS 3-5), mortality at 3 months after stroke, unsuccessful recanalization (mTICI 0-2a) and symptomatic intracranial hemorrhage (sICH, defined by ECASS-II-/III-criteria).

resultsOf 13,306 eligible patients, 892 were ⩾90 years old (6.7%). The very elderly had a higher median National Institutes of Health Stroke Scale (NIHSS) on admission (16 vs 14) and were more likely to have a pre-stroke mRS of 3-5 (38.0% vs 8.7%). The odds of poor functional outcome (ORadjusted 2.35 (95%-CI 1.87-2.97); 61.6% vs 38.7%), death (ORadjusted 3.04 (95%-CI 2.60-3.55); 53.9% vs 21.3%) and unsuccessful recanalization (ORadjusted 1.34 (95%-CI 1.14-1.57); 32.4% vs 27.2%) were higher in patients aged ⩾90 years. The odds of sICH did not differ (ORadjusted 0.92 (95%-CI 0.66-1.28); 5.1% vs 5.0%). DISCUSSION AND

conclusionEVT-treated stroke patients ⩾90 years had higher odds of poor functional outcome, mortality and unsuccessful recanalization than younger patients. However, the probability of sICH after EVT was not increased. The decision in favor of or against EVT in the very elderly should not be based on age alone.

Indexed as

Brain IschemiaEndovascular ProceduresIschemic StrokeStrokeAgedAged, 80 and overAge FactorsCohort StudiesFemaleHumansMaleProspective StudiesRegistriesTreatment Outcomeageelderly%Endovascular therapyintracranial hemorrhagestroke

Identifiers

PMID41614520
PMCPMC12866211

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.