Evidence map›Paper›PMID 41614534›Full record

Observational studyEuropean stroke journal2026

Cardiovascular risk factor control in patients with covert brain infarcts in the prospective SILENT cohort study.

Alice de Vautibault, Adnan Mujanovic, Valentin Amar, Laurent Roten, Urs Fischer, Marialuisa Zedde, Rosario Pascarella, Michail Giannakakis, Vasilis Tentoulouris, Elias Auer and 13 more

Erratum issued Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05685069 (Prevalence of Attributable Etiology and Modifiable Stroke Risk Factors in Patients With Covert Brain Infarctions), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05685069 recruitingnot on this map

Prevalence of Attributable Etiology and Modifiable Stroke Risk Factors in Patients With Covert Brain Infarctions (CBI-registry)

TypeobservationalSponsorInsel Gruppe AG, University Hospital BernRan2019 to 2026Enrolled230ConditionsSilent Stroke, Silent Cerebral Infarct, Covert Brain Infarct, Covert Brain Infarction
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Alice de VautibaultNeurology Department, Centre Hospitalier Universitaire de Tours, Université de Tours, Tours, France.
Adnan MujanovicInstitute of Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Valentin AmarNeurology Department, Centre Hospitalier Universitaire de Tours, Université de Tours, Tours, France.
Laurent RotenDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-0827-1329
Urs FischerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Marialuisa ZeddeAzienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Neurology Unit-Stroke Unit, Reggio Emilia, Italy.
Rosario PascarellaNeuroradiology Unit, Ospedale Santa Maria della Misericordia, AULSS5 Polesana, Rovigo, Italy.
Michail GiannakakisDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Vasilis TentoulourisDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Elias AuerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Bernhard SiepenDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Marta Olive GadeaInstitute of Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Arsany HakimInstitute of Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Christina MartiDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Anna BoronyloDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Morin BeyelerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Jean-Philippe CottierDepartment of Diagnostic and Interventional Neuroradiology, University Hospital of Tours, Tours, France.
Grégoire BoulouisDepartment of Diagnostic and Interventional Neuroradiology, University Hospital of Tours, Tours, France.
Laurent FauchierDepartment of Cardiology, Tours University Hospital, Tours, France.
Anne BernardDepartment of Cardiology, Tours University Hospital, Tours, France.
Jérôme RoumyMedical Imaging Department, Hôpital Bretonneau, CHU Tours, Tours, France.
Thomas MeinelDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Marco PasiNeurology Department, Centre Hospitalier Universitaire de Tours, Université de Tours, Tours, France.ORCID 0000-0001-9976-2459

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCovert brain infarctions (CBIs) are associated with cardiovascular risk factors (cvRFs). We aimed to evaluate the presence and therapeutic implications of modifiable cvRFs in patients with incidentally discovered CBI on routine neuroimaging. PATIENTS AND

methodsThe SILENT cohort (NCT05685069) is a prospective, multicentred European cohort recruiting patients with incidentally detected focal CBIs on routine MRI, without prior clinical stroke. Modifiable cvRFs and their control were assessed using applicable international guidelines during a dedicated outpatient visit, including a clinical examination and laboratory work-up. Associations between cvRF profiles and the number of CBIs were analysed using linear regression.

resultsWe included 231 patients (mean age 65 years, n = 130 [56%] male) with a total of 445 CBI lesions. Most CBIs were of lacunar type (n = 226; 51%) and the most common location was the cerebellum (n = 220; 50%). One hundred and fifty (65%) patients had at least 1, 112 (49%) at least 2 and 56 (24%) at least 3 known modifiable cvRFs. Among hypertensive patients, 69 (53%) had uncontrolled hypertension; 22 (65%) of diabetics were insufficiently controlled and 74 (58%) patients with dyslipidaemia had poorly controlled low-density lipoprotein cholesterol. Therapeutic measures were made for 144 patients (62%), including antiplatelet initiation in 107 (46%) and a statin in 69 (30%). The number of cvRFs per patient was significantly associated with the number of CBIs, rate ratio 1.08 (95% Confidence Interval (CI), 1.04-1.13).

conclusionIn patients with incidentally discovered CBI, we found a high burden of poorly controlled cvRFs. Our findings highlight the importance and yield of a dedicated clinical and laboratory assessment of cvRFs in patients with CBIs.

Indexed as

Brain InfarctionCardiovascular DiseasesHeart Disease Risk FactorsAgedAged, 80 and overCohort StudiesFemaleHumansHypertensionMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRisk Factorsantiplatelet agentbrain MRIcardiovascular risk factors (cvRFs)covert cerebral infarction (CBI)high blood pressure (HBP)lacunesilent cohortstatin

Identifiers

PMID41614534
PMCPMC12866629

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.