Evidence map›Paper›PMID 41614545›Full record

ArticleAging cell2026

Oxytocin, Epigenetic Aging, and the Social Regulation of Health: A Lifecourse Perspective on the Maejima et al. Findings.

Kerstin Uvnäs-Moberg, Mechthild M Gross, Jean Calleja-Agius, Jonathan D Turner

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Kerstin Uvnäs-MobergDepartment of Animal Environment and Health, Section of Anthrozoology and Applied Ethology, Swedish University of Agricultural Sciences, Skara, Sweden.
Mechthild M GrossMidwifery Research and Education Unit, Hannover Medical School, Hannover, Germany.
Jean Calleja-AgiusDepartment of Anatomy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Jonathan D TurnerImmune Endocrine Epigenetics Research Group, Department of Infection and Immunity, Luxembourg Institute of Health, Esch sur Alzette, Luxembourg.ORCID 0000-0002-2760-1071

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The elegant work by Maejima et al. recently published in Aging Cell reveals a previously unrecognized mechanism linking age-related oxytocin (OXT) decline to epigenetic remodeling, mitochondrial dysfunction, and systemic inflammation (Maejima et al. 2025). Beyond documenting this relationship, the authors demonstrate its remarkable reversibility through nasal OXT administration. These findings provide the first molecular evidence supporting what has long been proposed: that the OXT system functions as a fundamental long-term regulator of health across the entire lifespan, from early development through aging (Moberg 2024, 2003; Uvnas-Moberg 1998). The current work now gives a tantalizing glimpse into the epigenetic mechanism behind this life course regulation.

Indexed as

AgingEpigenesis, GeneticOxytocinAnimalsHumansOxytocinDNA methylationearly life programmingepigenetic agingHPA axislifecourse epidemiologynoradrenergic/sympathetic nervous systemoxytocinpersonalized epigenetic medicinesocial connectionTET enzymes

Identifiers

PMID41614545
PMCPMC12856773

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.