Evidence map›Paper›PMID 41614746›Full record

ReviewCurrent issues in molecular biology2025

Oxytocin Deficiency in Childhood and Adolescence: Clinical Features, Diagnostic Challenges and Therapeutic Perspectives.

Roberto Paparella, Arianna Bei, Irene Bernabei, Cinzia Fiorentini, Norma Iafrate, Roberta Lucibello, Lavinia Marchetti, Francesca Pastore, Vittorio Maglione, Marcello Niceta and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Roberto PaparellaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-7020-1471
Arianna BeiDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Irene BernabeiDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Cinzia FiorentiniDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0009-0003-0857-6039
Norma IafrateDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Roberta LucibelloDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Lavinia MarchettiDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Francesca PastoreDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Vittorio MaglioneDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-2404-2806
Marcello NicetaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-4766-7753
Marco FioreInstitute of Biochemistry and Cell Biology (IBBC-CNR), c/o Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6806-9715
Brunella CarontiDepartment of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy.
Mario VitaliASUR Marche, AV4, 60131 Ancona, Italy.
Ida PucarelliDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Luigi TaraniDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-5958-9364

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxytocin (OXT), traditionally linked to reproductive physiology, is now recognized as an important regulator of metabolic, skeletal, and socio-emotional processes. In children and adolescents, oxytocin deficiency (OXT-D) represents a significant but frequently underdiagnosed neuroendocrine disturbance, particularly in hypothalamic-pituitary disorders and syndromic conditions such as Prader-Willi and Schaaf-Yang. Experimental and clinical evidence suggests that OXT-D may contribute to altered appetite regulation, reduced energy expenditure, impaired bone health, and socio-emotional vulnerability, even when other pituitary axes are adequately replaced. Diagnostic evaluation remains challenging due to OXT's short half-life, pulsatile secretion, and the limited reliability of current assay platforms, which restrict the clinical utility of peripheral measurements or dynamic testing in pediatric practice. Intranasal OXT-the most extensively studied therapeutic approach-shows good short-term tolerability and context-dependent behavioral benefits, though long-term efficacy and safety remain insufficiently defined. Advancing the field will require standardized diagnostic criteria, more reliable biomarkers, and precision-medicine strategies accounting for developmental stage and genetic background. This review summarizes current knowledge on pediatric OXT-D and highlights priorities for future translational and clinical research.

Indexed as

clinical trialshypothalamic-pituitary disordersoxytocinpediatricsPrader–Willi syndrome

Identifiers

PMID41614746
PMCPMC12731813

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.