CRHR1 Gene Copy Number Variations, Chronic Viral Infections, and Age as Correlates of Cognitive Impairment in Adults After SARS-CoV-2 Infection.

Yekaterina Hovhannisyan, Hermine Yeritsyan, Hayk Harutyunyan, Allen Azizian, Konstantin Yenkoyan

Abstract read

In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yekaterina HovhannisyanNeuroscience Laboratory, COBRAIN Center, Yerevan State Medical University Named After Mkhitar Heratsi, Yerevan 0025, Armenia.

Hermine YeritsyanNeuroscience Laboratory, COBRAIN Center, Yerevan State Medical University Named After Mkhitar Heratsi, Yerevan 0025, Armenia.

Hayk HarutyunyanNeuroscience Laboratory, COBRAIN Center, Yerevan State Medical University Named After Mkhitar Heratsi, Yerevan 0025, Armenia.ORCID 0000-0001-5674-5130

Allen AzizianDepartment of Criminology, California State University, Fresno, CA 93740, USA.

Konstantin YenkoyanNeuroscience Laboratory, COBRAIN Center, Yerevan State Medical University Named After Mkhitar Heratsi, Yerevan 0025, Armenia.ORCID 0000-0003-3346-4306

Funding

State Committee of Science 25YSMU-CON-I-3A

6 · The paper itself

Abstract

Cognitive impairment is a frequent but heterogeneous consequence of SARS-CoV-2 infection, with objective cognitive deficits not always aligning with subjective cognitive complaints. Age, nutritional status, and stress-related biological pathways may contribute to this variability. The corticotropin-releasing hormone receptor 1 (CRHR1), a key regulator of stress and neuroendocrine responses, represents a biologically plausible candidate for post-infection cognitive vulnerability. In this pilot case-control study, we investigated associations between

Indexed as

cognitive impairmentcopy number variationsCRHR1 geneMOCARBANSSARS-CoV-2 infectionyoung and middle-aged individuals

Identifiers

PMID41614899

DOI10.3390/cimb48010069

PMCPMC12839784

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.