Evidence map›Paper›PMID 41615531›Full record

ArticleEJNMMI research2026

A peptide nucleic acid-based pretargeting approach using

Hongcheng Li, Xin Xiang, Lili Guan, Jie Wang, Yuyue Feng, Zhu Xia, Wenbo Li, Jia Li, Hua Pang, Zhengjie Wang

Abstract read
In one paragraph

Article in EJNMMI research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongcheng LiDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400042, P. R. China.
Xin Xiang
Lili GuanDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400042, P. R. China.
Jie WangDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400042, P. R. China.
Yuyue FengDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400042, P. R. China.
Zhu XiaDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400042, P. R. China.
Wenbo LiDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400042, P. R. China.
Jia LiDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400042, P. R. China.
Hua PangDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400042, P. R. China. phua1973@163.com.ORCID http://orcid.org/0000-0001-6601-3208
Zhengjie WangDepartment of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, 400042, P. R. China. bkzg1234@163.com.ORCID http://orcid.org/0000-0003-4156-151X

Funding

Chongqing Municipal Science and Technology Bureau CSTB2024TIAD-STX0048Innovative Research Group Project of the National Natural Science Foundation of China 82472019National Natural Science Foundation 82102093Natural Science Foundation of Chongqing Municipality CSTB2023NSCQ-MSX0097Natural Science Foundation of Chongqing Municipality CSTB2025NSCQ-GPX1138
6 · The paper itself

Abstract

backgroundAlthough molecular tumor-targeting peptides modified with albumin-binding domains can enhance tumor probe uptake and prolong tumor retention time, the prolonged systemic circulation resulting from this modification also increases radiation exposure to normal tissues. This study aims to validate that peptide nucleic acid (PNA)-mediated pretargeted

results

conclusionsCompared to conventional non-pretargeted radionuclide therapy, PNA-based pretargeted

Indexed as

161TbPNAPretargetingRadionuclide therapy

Identifiers

PMID41615531
PMCPMC12929770

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.