Evidence map›Paper›PMID 41615743›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A J-domain protein enhances memory by promoting physiological amyloid formation in

Kyle Patton, Yangyang Yi, Raj Burt, Kevin Kan-Shing Ng, Mayur Mukhi, Peerzada Shariq Shaheen Khaki, Ruben Hervas, Kausik Si

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kyle PattonStowers Institute for Medical Research, Kansas City, MO 64110.
Yangyang YiSchool of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.ORCID 0009-0007-4066-6818
Raj BurtStowers Institute for Medical Research, Kansas City, MO 64110.
Kevin Kan-Shing NgSchool of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.ORCID 0009-0007-1483-9658
Mayur MukhiSchool of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.ORCID 0000-0002-5626-3198
Peerzada Shariq Shaheen KhakiSchool of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.ORCID 0000-0002-2237-8800
Ruben HervasSchool of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.ORCID 0000-0001-6393-6058
Kausik SiStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0002-9613-6273

Funding

Stowers Institute for Medical Research (SIMR) SIMR
6 · The paper itself

Abstract

Memory requires experience-dependent alterations in the synaptic proteome. Chaperones interface between the environment and the proteome. Manipulating J-domain protein (JDP) chaperones, the most diverse family of chaperones, in a

Indexed as

AmyloidDrosophila melanogasterDrosophila ProteinsMemoryMolecular ChaperonesAnimalsmRNA Cleavage and Polyadenylation FactorsNeuronsProtein DomainsTranscription FactorsAmyloidDrosophila ProteinsMolecular ChaperonesmRNA Cleavage and Polyadenylation FactorsOrb2 protein, DrosophilaTranscription Factorsamyloidchaperonememory

Identifiers

PMID41615743
PMCPMC12867707

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.