Evidence map›Paper›PMID 41616773›Full record

ArticleCancer cell2026

Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance.

Maximilian Haist, Marc-A Baertsch, Nathan E Reticker-Flynn, Guolan Lu, Tim N Kempchen, Pauline Chu, Gustavo Vazquez, Han Chen, John B Sunwoo, Weiruo Zhang and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Maximilian HaistDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Department of Dermatology, University Medical Center Mainz, Mainz, Germany.
Marc-A BaertschDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center, Heidelberg, Germany.
Nathan E Reticker-FlynnDepartment of Otolaryngology, Stanford University, Stanford, CA, USA.
Guolan LuDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA; Department of Otolaryngology, Stanford University, Stanford, CA, USA.
Tim N KempchenDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA; Molecular Biosciences/Cancer Biology Program, Heidelberg University, Heidelberg, Germany; German Cancer Research Center, DKFZ, Heidelberg, Germany; Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany.
Pauline ChuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Gustavo VazquezDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Han ChenDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
John B SunwooClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center, Heidelberg, Germany; Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Weiruo ZhangDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA; Departments of Biological Sciences and Computer Science, Purdue University, West Lafayette, IN, USA.
Eyiwunmi LaseindeDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Bonny AdamiDepartment of Pathology, University Medical Center Mainz, Mainz, Germany.
Stefanie ZimmerDepartment of Pathology, University Medical Center Mainz, Mainz, Germany.
Justus KaufmanDepartment of Radiation Oncology and Radiotherapy, University Medical Center Mainz, Mainz, Germany.
Quynh Thu LeDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Andrew J GentlesDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA; Department of Medicine, Stanford University, Stanford, CA, USA.
Christina S KongDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Sylvia K PlevritisDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA.
Yury GoltsevDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
John W HickeyDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Garry P NolanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: gnolan@stanford.edu.

Funding

Translational Biology CoreP01CA257907 · NCI · STANFORD UNIVERSITY · PI Edward E. Graves · 2022 to 2026
$12.0M
Systems Biology of Tumor-Immune-Stromal Interactions in Metastatic ProgressionU54CA274511 · NCI · STANFORD UNIVERSITY · PI JOSEPH B SHRAGER · 2023 to 2026
$9.5M
The role of Galectin-1 in shaping the immune suppressive landscape in head and neck cancerR01DE029672 · NIDCR · STANFORD UNIVERSITY · PI LE, QUYNH-THU XUAN · 2021 to 2025
$2.9M
NCI NIH HHS P01 CA257907NCI NIH HHS U54 CA274511NIDCR NIH HHS R01 DE029672
6 · The paper itself

Abstract

Lymph node (LN) colonization in cancer is linked to poor prognosis. Evidence suggests that LN colonization induces systemic immunosuppression, facilitating distant metastasis. We investigated LN-mediated immunosuppression in patients with head-and-neck cancer using spatial proteomics, spatial transcriptomics, and an in vivo model of melanoma LN metastasis. Both primary tumors and paired LNs of nodal-positive patients exhibit enhanced interferon-γ signaling and an enrichment of immunosuppressive myeloid cells and cancer-associated fibroblasts (CAFs). The spatial intersection of these myeloid-CAF-enriched niches with perifollicular T cell zones and LN follicles is linked to enhanced T cell dysfunction and Treg activation therein, thereby driving architectural LN remodeling. These immune suppressive changes extend to adjacent non-tumor-involved LN regions and nearby tumor-free LNs, but were not detected in LNs of non-cancer patients, reflecting a systemic effect that compromises anti-tumor immunity beyond the tumor-involved LN. Hence, our findings establish LN colonization as an active driver of systemic immunosuppression, facilitating metastatic progression.

Indexed as

Cancer-Associated FibroblastsHead and Neck NeoplasmsImmune ToleranceLymph NodesMyeloid CellsAnimalsFemaleHumansInterferon-gammaLymphatic MetastasisMelanomaMiceT-Lymphocytes, RegulatoryTumor MicroenvironmentInterferon-gammacancer-associated fibroblastshead-and-neck cancerimmunomodulationlymph nodesmetastasismultiplex imagingspatial contextspatial transcriptomicstumor immune evasiontumor microenvironment

Identifiers

PMID41616773
PMCPMC13289805

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.