Phosphatidylserine transporters ORP5 and ORP8 control cholesterol trafficking from the plasma membrane to the endoplasmic reticulum.

Fanqian N Xiao, Dougall M Norris, Guang Yang, Yang E Li, Andrew J Brown, Hongyuan Yang

Abstract read

In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fanqian N XiaoSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.

Dougall M NorrisSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia; Faculty of Health and Medicine, University of Sydney, Sydney, New South Wales, Australia.

Guang YangSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.

Yang E LiSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.

Andrew J BrownSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia. Electronic address: aj.brown@unsw.edu.au.

Hongyuan YangSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, TX, USA. Electronic address: hongyuan.yang@uth.tmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphatidylserine (PS), the most abundant negatively charged phospholipid in mammalian cells, is made in the endoplasmic reticulum (ER) but concentrated in the plasma membrane (PM). Similarly, cellular cholesterol is synthesized in the ER, yet enriched in the PM. Recently, PS has been shown to govern the transport of low-density lipoprotein-derived cholesterol from the PM to the ER. Here, we investigated how cholesterol regulates the delivery of PS from the ER to PM by the lipid-transfer proteins, ORP5 and ORP8. Adding exogenous cholesterol markedly increased the level of PI(4,5)P

Indexed as

Cell MembraneCholesterolEndoplasmic ReticulumPhosphatidylserinesReceptors, SteroidAnimalsBiological TransportHumansMembrane ProteinsOxysterol Binding ProteinsCholesterolGRAMD1B protein, humanMembrane ProteinsOxysterol Binding ProteinsPhosphatidylserinesReceptors, Steroidcholesterol/traffickinglipid transfer proteinsmembranemembrane contact sitesnonvesicular lipid transportphospholipid/metabolismphospholipidsphospholipids/traffickingtransport

Identifiers

PMID41616826

DOI10.1016/j.jlr.2026.100989

PMCPMC12962173

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.