Evidence map›Paper›PMID 41617804›Full record

ArticleScientific reports2026

Rapid clearance of bacteria from maternal bloodstream after delivery in pregnancies complicated by preterm pre-labor rupture of the membranes.

Catalin S Buhimschi, Guomao Zhao, Kara M Rood, Lindsey Solden, Shaylyn D Webster, Manel Guessas, Stephanie Hearne, Anthony Moussa, Sonia Guessas, Hongwu Jing and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Catalin S BuhimschiDepartment of Obstetrics and Gynecology, University of Illinois Chicago College of Medicine, Chicago, IL, 60612, USA. csb01@uic.edu.
Guomao ZhaoDepartment of Obstetrics and Gynecology, University of Illinois Chicago College of Medicine, Chicago, IL, 60612, USA.
Kara M RoodDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The Ohio State University College of Medicine, Columbus, OH, 43215, USA.
Lindsey SoldenCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA.
Shaylyn D WebsterDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The Ohio State University College of Medicine, Columbus, OH, 43215, USA.
Manel GuessasCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA.
Stephanie HearneCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA.
Anthony MoussaCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA.
Sonia GuessasCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA.
Hongwu JingDepartment of Obstetrics and Gynecology, University of Illinois Chicago College of Medicine, Chicago, IL, 60612, USA.
Kathryn BerrymanDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The Ohio State University College of Medicine, Columbus, OH, 43215, USA.
William E AckermanDepartment of Obstetrics and Gynecology, University of Illinois Chicago College of Medicine, Chicago, IL, 60612, USA.
Irina A BuhimschiDepartment of Obstetrics and Gynecology, University of Illinois Chicago College of Medicine, Chicago, IL, 60612, USA.

Funding

Futures Matter: Transformative Transdisciplinary Summer Research ProgramR25HD086885 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI ROGERS, LYNETTE KAY · 2016 to 2020
$535k
NICHD NIH HHS R25 HD086885
6 · The paper itself

Abstract

Preterm pre-labor rupture of membranes (PPROM) increases maternal and neonatal sepsis risk, yet its association with maternal microbial translocation and systemic inflammation remains unclear. We investigated whether PPROM is linked to microbial DNA in maternal blood (MB) and inflammatory responses around delivery. In 66 PPROM patients (median GA: 32 weeks), MB was collected pre-delivery and within 1 h postpartum. Fetal membranes (FM) and placental tissues were sampled immediately after delivery. Bacterial load and diversity were analyzed via 16 S rDNA qPCR and sequencing. Maternal cytokines were quantified by multiplex immunoassay, and fetal inflammatory exposure (Triple I) assessed using histological chorioamnionitis (HCA), cord blood haptoglobin, and IL-6. Bacterial DNA was detected in maternal blood (MB) pre- and post-delivery, with a significant postpartum decline (p = 0.004). FM carried higher bacterial load and biodiversity than placenta (p < 0.001), dominated by Mycoplasma spp. Maternal IL-6 and IL-10 levels rose postpartum (p < 0.05), particularly in cases with fetal inflammatory exposure. Limited overlap was found between MB and tissue microbial taxa. In conclusion, bacterial DNA is detectable in maternal circulation in patients with PPROM before birth but rapidly clears postpartum alongside a robust cytokine surge, suggesting efficient clearance and dynamic inflammatory changes.

Indexed as

Premature Rupture of Fetal MembranesAdultBacterial LoadChorioamnionitisCytokinesDNA, BacterialFemaleHumansInterleukin-6PlacentaPostpartum PeriodPregnancyCytokinesDNA, BacterialInterleukin-6

Identifiers

PMID41617804
PMCPMC12914011

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.