ArticleScientific reports2026
High on-clopidogrel platelet reactivity among diabetic female patients with acute ischaemic stroke.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies suggest that diabetes-related thrombotic risk differs by sex. This raises the question of whether this sex-based disparity influences the effectiveness of antithrombotic therapy. Herein, we aimed to investigate the association between sex, diabetes mellitus, and on-clopidogrel platelet reactivity in acute ischaemic stroke patients. This cross-sectional analysis used baseline data from a single-center cohort study where we recruited 650 adults diagnosed with acute ischaemic stroke receiving a 300 mg loading dose of clopidogrel from October 2022 to April 2024. Platelet reactivity was measured using the VerifyNow P2Y12 assay. The analysis was conducted using a multivariable linear regression model with an interaction term between sex and diabetes status. The overall mean platelet reactivity unit (PRU) in our study population was 168.3 ± 61.1 and was significantly higher among diabetic patients (177 ± 60 vs. 162 ± 61, p = 0.004). In our model, neither sex nor diabetes alone were significantly associated with PRU. However, the interaction between female sex and diabetes was associated with a significant increase in PRU by 20 units (95% CI: 3.0 to 37, p = 0.021). Cumulatively, diabetic female patients exhibited a PRU increase of 27.3 units compared to non-diabetic male patients, highlighting a subgroup that may require further clinical assessment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.