Evidence map›Paper›PMID 41618101›Full record

ArticleNPJ Parkinson's disease2026

Metagenomics indicates an interplay of the microbiome and functional pathways in Parkinson's disease.

Sarah Jaehwa Park, Barış Erhan Özdinç, Kathryn Grace Coker, Dana M Walsh, Devon J Fox, Samantha Evans, Joshua Farahnik, Kelly Moffat, Margaret Boomgaarden, Laurie K Mischley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Beyond bacteria: a multi-omics view of the gut-brain axis in Parkinson's disease.Frontiers in cellular and infection microbiology · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah Jaehwa ParkBastyr University Research Institute, Bastyr University, Kenmore, WA, USA.
Barış Erhan ÖzdinçCosmosID Inc., Germantown, MD, USA.
Kathryn Grace CokerBastyr University Research Institute, Bastyr University, Kenmore, WA, USA.
Dana M WalshCosmosID Inc., Germantown, MD, USA.
Devon J FoxParkinson Center for Pragmatic Research, Shoreline, WA, USA.
Samantha EvansBastyr University Research Institute, Bastyr University, Kenmore, WA, USA.
Joshua FarahnikBastyr University Research Institute, Bastyr University, Kenmore, WA, USA.
Kelly MoffatCosmosID Inc., Germantown, MD, USA.
Margaret BoomgaardenBastyr University Research Institute, Bastyr University, Kenmore, WA, USA.
Laurie K MischleyBastyr University Research Institute, Bastyr University, Kenmore, WA, USA. lmischley@bastyr.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies suggest there are distinct gut microbial and functional variations in patients with Parkinson's disease (PwPD) that may reveal potential microbiome signatures or biomarkers to aid in early detection of the disease. In this case-control study, we used whole genome sequencing to compare the stool samples of 55 PwPD to 42 healthy controls (HC) from a public database (BioProject Accession PRJEB39223). For bacterial phyla, we observed a greater relative abundance in Firmicutes and Actinobacteria among PwPD, while that of Bacteroidetes was lower. For phages, PwPD had a greater relative abundance of Siphoviridae, Tectiviridae, and Podoviridae, while Microviridae was lower. Moreover, we described 10 functional pathways that most significantly differed between PwPD and HC (all P < 0.0001). In conclusion, significant differences were observed in gut bacteria, phages, and functional pathways between PwPD and HC that both support and conflict with previous case-control studies and warrant further validation.

Identifiers

PMID41618101
PMCPMC12960697

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.