ArticleJournal of orthopaedic surgery and research2026
Associations between the serum follicle-stimulating hormone (FSH) levels and intervertebral disc degeneration severity during the menopausal transition.
Article in Journal of orthopaedic surgery and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Is Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging.Journal of clinical medicine · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to examine the relationships between the serum follicle-stimulating hormone (FSH) levels and lumbar intervertebral disc degeneration (IVDD) severity in women undergoing the menopausal transition.
methodsConsecutive women aged 45-55 years were enrolled in the cross-sectional study. Fasting serum FSH levels were measured, and lumbar IVDD severity was evaluated using modified Pfirrmann grading on magnetic resonance images.
resultsA total of 324 subjects, including 117 pre, 62 peri- and 145 postmenopausal women, were included. Compared with the pre- and perimenopausal groups, the postmenopausal group demonstrated higher FSH levels and IVDD severity, which was better supported by an age-matched comparison. Notably, the serum FSH levels showed statistically positive correlations (P < 0.001) with L1/2 (r
conclusionThere were significant associations between elevated FSH levels and IVDD severity in women during the menopausal transition, which is beneficial for further exploring the potential mechanisms underlying postmenopausal IVDD. These findings suggest that FSH may be a novel biomarker for assessing IVDD risk in menopausal women and highlight the FSHR as a potential therapeutic target for mitigating disc degeneration.
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Registered trials
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