Evidence map›Paper›PMID 41618372›Full record

ArticleActa neuropathologica communications2026

Inhibition of p38 MAPK after repetitive mTBI ameliorates immune signaling and functional deficits.

Chenxing Li, Martin N Griffin, Sydney E Triplett, Anna E Silverio, Elizabeth Pettit, Alivia M Rohrer, Jacob P Callaway, Pranavvarma V Munagapati, Paul F Saah, Paul I Sanz and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Chenxing LiThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30318, USA.
Martin N Griffin *George W. Woodruff School of Mechanical Engineering, , Georgia Institute of Technology, Atlanta, GA, 30318, USA.
Sydney E Triplett *The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30318, USA.
Anna E SilverioDepartment of Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30318, USA.
Elizabeth PettitDepartment of Neuroscience, Georgia Institute of Technology, Atlanta, GA, 30318, USA.
Alivia M RohrerThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30318, USA.
Jacob P CallawayThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30318, USA.
Pranavvarma V MunagapatiDepartment of Neuroscience, Georgia Institute of Technology, Atlanta, GA, 30318, USA.
Paul F SaahDepartment of Anthropology and Human Biology, Emory University, Atlanta, GA, 30322, USA.
Paul I SanzDepartment of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Felix G Rivera MoctezumaGeorge W. Woodruff School of Mechanical Engineering, , Georgia Institute of Technology, Atlanta, GA, 30318, USA.
Abigail HolbertonGeorge W. Woodruff School of Mechanical Engineering, , Georgia Institute of Technology, Atlanta, GA, 30318, USA.
Angela GomezDepartment of Neuroscience, Georgia Institute of Technology, Atlanta, GA, 30318, USA.
Erin M BuckleyThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30318, USA. erin.buckley@bme.gatech.edu.
Levi B WoodThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30318, USA. levi.wood@me.gatech.edu.

Funding

Role of Neuronal p38 MAPK After Repetitive Mild TBIR01NS115994 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI BUCKLEY, ERIN MCGUIRE, WOOD, LEVI BENJAMIN · 2020 to 2024
$2.3M
NIH HHS R01 NS115994
6 · The paper itself

Abstract

Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can lead to long-term neurological impairments. Following mechanical impact, increasing evidence suggests that the brain undergoes an inflammatory cascade, leading to chronic neuroinflammation and persistent neurological deficits. While the p38 MAPK signaling pathway is implicated in severe TBI, its role in rmTBI is unclear. This study investigated whether small molecule inhibition of p38 MAPK with SB239063 reduces inflammatory response and functional deficits after repetitive mTBI in a mouse weight-drop model. In females, p38 MAPK inhibition reduced synaptic loss, cytokine upregulation, microglial reactivity, functional deficits, and transcript alterations while upregulating protective pathways. In males, p38 MAPK inhibition attenuated microglial changes and transcript alterations but had limited functional effects. Together, these findings suggest the role of p38 MAPK in driving injury consequences in a sex-dependent manner and highlight therapeutic potential for p38 MAPK inhibition after repetitive mTBI.

Indexed as

Brain ConcussionImidazolesp38 Mitogen-Activated Protein KinasesPyrimidinesAnimalsBrainCytokinesDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMicrogliaSignal TransductionCytokinesImidazolesp38 Mitogen-Activated Protein KinasesPyrimidinesSB 239063BulkCytokinesDepressionMicroglia activationMild traumatic brain injuryNeuroinflammationp38 MAPK

Identifiers

PMID41618372
PMCPMC12977694

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.