Evidence map›Paper›PMID 41619304›Full record

ArticleChemistry & biodiversity2026

Metabolite Profiling and Anticancer Evaluation of Iraqi Haloxylon articulatum Halophyte via LC-HRMS/MS, Molecular Docking, and ADMET Analysis.

Jihen Abidi, Amal Ben Hassena, Rania Ben Hmida, Łukasz Kulinowski, Erdi Can Aytar, Reyedh R Al-Rashidi, Mohamed Bouaziz

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jihen AbidiLaboratory of Electrochemistry and Environment, National School of Engineers of Sfax, University of Sfax, Sfax, Tunisia.
Amal Ben HassenaLaboratory of Electrochemistry and Environment, National School of Engineers of Sfax, University of Sfax, Sfax, Tunisia.
Rania Ben HmidaLaboratory of Electrochemistry and Environment, National School of Engineers of Sfax, University of Sfax, Sfax, Tunisia.
Łukasz KulinowskiDepartment of Chemistry of Natural Products, Medical University of Lublin, Lublin, Poland.
Erdi Can AytarDepartment of Horticulture, Faculty of Agriculture, Usak University, Uşak, Türkiye.
Reyedh R Al-RashidiDepartment of Basic Science, College of Dentistry, University of Kut, Wasit, Iraq.
Mohamed BouazizLaboratory of Electrochemistry and Environment, National School of Engineers of Sfax, University of Sfax, Sfax, Tunisia.ORCID https://orcid.org/0000-0001-9107-7027

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional medicinal plants are valuable sources of bioactive compounds used for therapeutic purposes. Haloxylon articulatum, a halophyte adapted to arid climate, has been consumed to treat several health issues. This study explores the phytochemical richness, the antioxidant, and the anticancer activities of a hydroalcoholic extract of H. articulatum through liquid chromatography-high-resolution mass spectrometry/mass spectrometry (LC-HRMS/MS), 2,2-diphenyl-1-picrylhydrazyl (DPPH) analysis, cytotoxicity testing, and computational analysis. Alkaloids, flavonoids, and phenolic acids were among numerous bioactive chemicals found within the extracts. The DPPH assay revealed a notable antioxidant activity. Using the cytotoxicity test, the major phytochemicals, N-caffeoyltyramine and sinapoyltyramine, exhibited anticancer activity against gastric cancer cell lines AGS and NCI-N87, with IC

Indexed as

Antineoplastic Agents, PhytogenicAntioxidantsMolecular Docking SimulationPlant ExtractsAlkaloidsBiphenyl CompoundsCell Line, TumorCell ProliferationChromatography, LiquidDrug Screening Assays, AntitumorErbB ReceptorsFlavonoidsHumansMolecular StructurePicratesStructure-Activity Relationship1,1-diphenyl-2-picrylhydrazylAlkaloidsAntineoplastic Agents, PhytogenicAntioxidantsBiphenyl CompoundsErbB ReceptorsFlavonoidsPicratesPlant Extractsabsorptionand toxicity (ADMET) analysisanticancer agentsantioxidant activitycytotoxicitydistributionepidermal growth factor receptor (EGFR) kinaseexcretionHaloxylon articulatummetabolismmolecular docking

Identifiers

PMID41619304
PMCPMC12860547

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.