Evidence map›Paper›PMID 41619762›Full record

ArticleJournal of the National Cancer Institute2026

Neurocognitive impairment and financial hardship in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Daniel J Zheng, Shalini Bhatia, Sedigheh Mirzaei, Richard Aplenc, Gregory T Armstrong, Kira Bona, Tara M Brinkman, Pim Brouwers, Kim Edelstein, Kelly Getz and 9 more

Abstract read
In one paragraph

Article in Journal of the National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Daniel J ZhengChildren's Hospital of Philadelphia, PA, USA.
Shalini BhatiaSt Jude Children's Research Hospital, TN, USA.
Sedigheh MirzaeiSt Jude Children's Research Hospital, TN, USA.
Richard AplencChildren's Hospital of Philadelphia, PA, USA.
Gregory T ArmstrongSt Jude Children's Research Hospital, TN, USA.
Kira BonaDana-Farber/Boston Children's Cancer and Blood Disorders Center, MA, USA.
Tara M BrinkmanSt Jude Children's Research Hospital, TN, USA.
Pim BrouwersNational Institutes of Health, Washington, D.C, USA.
Kim EdelsteinPrincess Margaret Cancer Centre, Canada.
Kelly GetzUniversity of Pennsylvania, PA, USA.
I-Chan HuangSt Jude Children's Research Hospital, TN, USA.
Anne C KirchhoffHuntsman Cancer Institute, University of Utah, UT, USA.
Sogol Mostoufi-MoabChildren's Hospital of Philadelphia, PA, USA.
Elyse R ParkMassachusetts General Hospital, MA, USA.
Claire SnyderJohns Hopkins University, MD, USA.
K Robin YabroffAmerican Cancer Society, GA, USA.
Yutaka YasuiSt Jude Children's Research Hospital, TN, USA.
Kevin KrullSt Jude Children's Research Hospital, TN, USA.
Paul C NathanThe Hospital for Sick Children, Toronto, Canada.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
Physician Scientist Training in Clinical OncologyK12CA076931 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STEPHEN Patrick HUNGER, LYNN M. SCHUCHTER · 1997 to 2026
$16.5M
EMPOWER Study: Promoting BC Screening in Women Who Survived Childhood Cancer Administrative SupplementR01CA134722 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI FORD, JENNIFER S, OEFFINGER, KEVIN CHARLES · 2009 to 2022
$6.6M
NCI NIH HHS K12 CA076931NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA134722NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

More than 60% of adult survivors of childhood cancer report medical financial hardship due to the cumulative costs of cancer-directed therapy and related chronic health conditions. Whether neurocognitive impairment as a late effect is associated with increased financial hardship is unknown. In a large national cohort of 3023 adult survivors of childhood cancer, we observed a dose-dependent relationship between neurocognitive impairment and financial hardship outcomes. Individuals with 4 impaired neurocognitive domains had over 3-fold increased odds of debt collection (OR = 3.12, 95% CI = 1.91-5.09) and bankruptcy (OR = 3.77, 95% CI = 2.01-7.07) compared to individuals with no impaired neurocognitive domains. After adjusting for education, employment, and household income, the independent association between neurocognitive impairment and financial hardship outcomes persisted suggesting that other mechanisms may be at play. Neurocognitive impairment is an important risk factor for medical financial hardship in this patient population and should be considered for targeted screening and intervention.

Identifiers

PMID41619762
PMCPMC12927753

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.