Evidence map›Paper›PMID 41620538›Full record

ArticleAnnals of biomedical engineering2026

Fabrication of a Bioactive Human Adipose Extracellular Matrix Allograft Using Supercritical Carbon Dioxide.

Sophia Salingaros, Jini Jeon, Xue Dong, Samuel Medina, Matthew Liao, Ankita Sarkar, Eric Eisenhut, Tony Eisenhut, David Bednarski, Carlos Urrea De La Puerta and 2 more

Abstract read
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Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sophia SalingarosDepartment of Surgery, Division of Plastic Surgery, Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medicine, New York, NY, USA.
Jini JeonDepartment of Surgery, Division of Plastic Surgery, Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medicine, New York, NY, USA.
Xue DongDepartment of Surgery, Division of Plastic Surgery, Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medicine, New York, NY, USA.
Samuel MedinaDepartment of Surgery, Division of Plastic Surgery, Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medicine, New York, NY, USA.
Matthew LiaoDepartment of Surgery, Division of Plastic Surgery, Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medicine, New York, NY, USA.
Ankita SarkarNovaSterilis Inc, Lansing, NY, USA.
Eric EisenhutNovaSterilis Inc, Lansing, NY, USA.
Tony EisenhutNovaSterilis Inc, Lansing, NY, USA.
David BednarskiNovaSterilis Inc, Lansing, NY, USA.
Carlos Urrea De La PuertaNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Lawrence J BonassarNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Jason A SpectorDepartment of Surgery, Division of Plastic Surgery, Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medicine, New York, NY, USA. jas2037@med.cornell.edu.

Funding

Empire State Development's Division of Science, Technology and Innovation Centers for Advanced Technology (CAT) Grant FY2024
6 · The paper itself

Abstract

purposeAutologous fat grafting is widely used for soft tissue augmentation but hindered by unpredictable volume retention and donor site morbidity. Decellularized adipose extracellular matrix (DAM) represents a promising alternative. Herein we evaluate an injectable, human-derived DAM decellularized via supercritical carbon dioxide (scCO

methodsHuman adipose tissue was homogenized, delipidated, then underwent scCO

resultssDAM demonstrated a mean of 47 ng DNA/mg of dry weight, below the 50 ng/mg "complete" decellularization threshold. After 6 months, adipose flank volume was 307 mm

conclusionWe present the first description of scCO

Indexed as

Adipose TissueCarbon DioxideDecellularized Extracellular MatrixExtracellular MatrixTissue EngineeringAllograftsAnimalsFemaleHumansMiceMice, Inbred C57BLCarbon DioxideDecellularized Extracellular MatrixAdipose matrixDecellularizationSupercritical Co2Tissue engineering

Identifiers

PMID41620538

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.