ArticleJournal of neuroengineering and rehabilitation2026
Dynamic brain synergy uncovers functional neural coordination in Parkinson's disease under dopaminergic modulation.
Article in Journal of neuroengineering and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBrain synergy and redundancy are emerging as pivotal aspects to understand neural functions, providing insights into high-order information that traditional functional connectivity (FC) methods cannot access. Despite their significance, these aspects have not been investigated in Parkinson's disease (PD). This paper advances the understanding of synergy and redundancy by integrating them with dynamic analysis, which is essential in the investigation of PD.
methodsDynamic brain synergy and redundancy were developed and quantified by the constructed dynamic information decomposition framework, and was applied to walking-state functional near-infrared spectroscopy (fNIRS) signals of 63 PD patients undergoing dopaminergic treatment and 36 healthy controls.
resultsDynamic brain synergy was restored to normal levels following dopaminergic treatment. Dynamic FC could not access high-order neural information and had insignificant variations in dopaminergic modulation among PD patients, and dynamic brain redundancy also exhibited insignificant treatment-induced variations.
conclusionDynamic brain synergy offers an advancing perspective on neural dynamics and promises to uncover high-order functional biomarkers for PD early diagnosis and individualized treatment.
trial registrationThis study has been registered in Chinese Clinical Trial Registry (ChiCTR1900022655).
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