Observational studyBMC geriatrics2026
Comparative prognostic value of nutrition-inflammation indices for 1-year mortality in elderly intensive care unit patients: a retrospective observational study based on MIMIC-IV database.
Observational study in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMalnutrition and systemic inflammation are frequent in critically ill elderly patients and are strongly linked to poor outcomes. However, the relative prognostic performance of 6 commonly used nutrition–inflammation indices (mNUTRIC, PNI, CONUT, GNRI, HALP, and LAR) in elderly ICU patients has lacked validation in large-scale cohorts. This study aimed to compare the predictive performance of six such indices for 1-year all-cause mortality in elderly ICU patients.
methodsThis retrospective observational study was based on the Medical Information Mart for Intensive Care IV (MIMIC-IV, version 2.2) database. Patients aged ≥ 65 years with an ICU stay ≥ 24 h were included. Six indices (mNUTRIC, PNI, CONUT, GNRI, HALP, and LAR) were calculated using data within 24 h after ICU admission. The primary outcome was 1-year all-cause mortality. Receiver operating characteristic analysis and DeLong tests were used to compare predictive performance among indices.
resultsA total of 18 868 patients were included, of whom 5 939 (31.5%) died within one year. All indices were significantly associated with mortality, but mNUTRIC showed the highest discrimination (AUROC = 0.713, 95% CI 0.705–0.720, P < 0.001), outperforming the others. Patients with high mNUTRIC scores (≥ 4) had markedly higher 1-year mortality than those with low scores (47.0% vs. 19.2%, P < 0.001).
conclusionsAmong six nutritional–inflammatory indices, mNUTRIC provided the best prediction of 1-year mortality in elderly ICU patients. Early nutritional risk screening using mNUTRIC may help identify high-risk individuals for targeted interventions.
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