Evidence map›Paper›PMID 41620707›Full record

ArticleJournal of ovarian research2026

Night-restricted feeding preserves the ovarian circadian rhythm of IL-17 and promotes follicular development in prepubertal and pubertal rabbits.

Meng-Qi Zhu, Jian-Xiang Cheng, Chun-Hua Shan, Jie Huang, Ke-Hao Zhang, Yao Guo, Shuai He, Peng Liu, Zhong-Ying Liu, Zhong-Hong Wu

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Article in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meng-Qi ZhuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Jian-Xiang ChengState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Chun-Hua ShanState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Jie HuangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Ke-Hao ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Yao GuoState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Shuai HeState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Peng LiuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Zhong-Ying LiuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Zhong-Hong WuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China. wuzhh@cau.edu.cn.

Funding

Earmarked Fund for China Agriculture Research System CARS-43-D-2
6 · The paper itself

Abstract

backgroundIrregular sleep and eating patterns in modern lifestyles may disrupt reproductive rhythms, thereby impairing reproductive function in adult women. In livestock production, improper management may disturb livestock eating and activity rhythms, thereby reducing reproductive performance. However, whether disruptions in feeding times during the growth stage affect pubertal follicular development via the ovarian circadian rhythm regulation remains unclear.

resultsIn this study, rabbits were assigned to daytime feeding (DF) and night-restricted feeding (NRF) groups. At day 84, ovarian circadian transcriptome (4-hour intervals over a 24-hour period) revealed that NRF induced a circadian oscillation of the IL-17 signaling pathway, with peak expression occurring at night. Furthermore, NRF significantly accelerated the timing of puberty onset. At day 145, NRF promoted follicular development and enhanced granulosa cell proliferation. Ovarian diurnal transcriptome analysis (12-hour intervals over a 24-hour period) demonstrated that feeding time exerted sustained regulatory effects on the IL-17 signaling pathway. Notably, ovarian IL-17 protein levels in the NRF group exhibited a diurnal difference, with lower levels during the day and higher levels at night. In vitro experiments further demonstrated that rhythmic IL-17 stimulation, simulating the NRF group, promotes granulosa cell proliferation and enhances the rhythmic expression of core clock genes (BMAL1, CLOCK) as well as the cell cycle regulator WEE1.

conclusionFeeding time synchronized with endogenous circadian rhythms maintains the ovarian IL-17 rhythmicity, may contribute to promoting granulosa cell proliferation, driving follicular development, and ensuring timely pubertal onset. These findings suggest that the impact of feeding time on the onset of puberty and follicular development may be linked to the circadian rhythm of ovarian inflammatory signaling, offering new insights into the protection of reproductive health during puberty and the prevention of reproductive disorders via dietary timing adjustments.

Indexed as

Circadian RhythmInterleukin-17Ovarian FollicleOvaryAnimalsCell ProliferationFeeding BehaviorFemaleGranulosa CellsIntermittent FastingRabbitsSexual MaturationSignal TransductionInterleukin-17Circadian rhythmsFeeding timeFollicular developmentGranulosa cellIL-17

Identifiers

PMID41620707
PMCPMC12933993

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.