Evidence map›Paper›PMID 41621805›Full record

ArticleOphthalmology. Retina2026

Standardizing Measurement of Complete Retinal Pigment Epithelial and Outer Retinal Atrophy: Classification of Atrophy Meeting Report 8.

David Sarraf, Federico Corvi, Philip J Rosenfeld, Thomas Ach, Barbara Blodi, Ferdinando Bottoni, Mariano Cozzi, Usha Chakravarthy, Emily Y Chew, Karl Csaky and 23 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology. Retina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

David SarrafStein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. Electronic address: dsarraf@ucla.edu.
Federico CorviEye Clinic, Department of Biomedical and Clinical Sciences "Luigi Sacco, " Luigi Sacco Hospital, University of Milan, Milan, Italy.
Philip J RosenfeldBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Thomas AchDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Barbara BlodiDepartment of Ophthalmology and Visual Sciences, Fundus Photograph Reading Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Ferdinando BottoniEye Clinic, Department of Biomedical and Clinical Sciences "Luigi Sacco, " Luigi Sacco Hospital, University of Milan, Milan, Italy.
Mariano CozziEye Clinic, Department of Biomedical and Clinical Sciences "Luigi Sacco, " Luigi Sacco Hospital, University of Milan, Milan, Italy.
Usha ChakravarthyCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Emily Y ChewNational Eye Institute, National Institutes of Health, Bethesda, Maryland.
Karl CsakyTexas Retina Associates, Dallas, Texas.
Cathy CukrasF. Hoffmann-La Roche Ltd, Basel, Switzerland.
Christine A CurcioDepartment of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Frederick L FerrisOphthalmic Research Consultants, Waxhaw, North Carolina.
K Bailey FreundVitreous Retina Macula Consultants of New York, New York, New York.
Juan GrunwaldDepartment of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania.
Robyn H GuymerCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Department of Surgery (Ophthalmology), University of Melbourne, Melbourne, Australia.
Frank G HolzDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Glenn J JaffeDepartment of Ophthalmology, Duke University, Durham, North Carolina.
Sandra LiakopoulosDepartment of Ophthalmology, University of Cologne, Cologne, Germany; Department of Ophthalmology, Goethe-University Frankfurt, Frankfurt, Germany.
Tock Han LimNational Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
Jordi M MonésInstitut de la Màcula and Barcelona Macula Foundation, Barcelona, Spain.
Cynthia OwsleyDepartment of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Sergio PagliariniDepartment of Ophthalmology, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom.
Daniel PauleikhoffDepartment of Ophthalmology, St. Franziskus Hospital, Münster, Germany.
Steffen Schmitz-ValckenbergDepartment of Ophthalmology, University of Bonn, Bonn, Germany; John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
Richard F SpaideVitreous Retina Macula Consultants of New York, New York, New York.
Janet SparrowDepartments of Ophthalmology, Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
Ramin TadayoniRothschild Foundation Hospital, Paris, France; Ophthalmology Department, Université Paris Cité, AP-HP, Hôpital Lariboisière, Paris, France.
Adnan TufailInstitute of Ophthalmology, University College London, London, United Kingdom.
Francesco ViolaCà Granda Foundation, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy; Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, Italy.
Scott FraserTranslational Imaging Center, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California; Molecular and Computational Biology, University of Southern California, Los Angeles, California.
Giovanni StaurenghiEye Clinic, Department of Biomedical and Clinical Sciences "Luigi Sacco, " Luigi Sacco Hospital, University of Milan, Milan, Italy.
Srinivas R SaddaDoheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

Funding

Intramural NIH HHS Z99 EY999999
6 · The paper itself

Abstract

purposeTo highlight the role of en face OCT in the measurement of choroidal hypertransmission defects (hyperTDs) in complete retinal pigment epithelial and outer retinal atrophy (cRORA), and to refine the definition of retinal pigment epithelium (RPE)-related alterations associated with cRORA.

designConsensus meeting.

participantsPanel of retina specialists, including retinal imaging experts, reading center leaders, and retinal histologists.

methodsAs part of the Classification of Atrophy Meeting (CAM) program, an international group of experts analyzed and discussed the role of en face OCT in the assessment of cRORA. A structured study was conducted, consisting of an exercise to assess en face OCT cases, reviewed jointly during the eighth CAM meeting, and to explore the utility of this advanced tool for disease staging and progression. Additionally, definitions previously applied to RPE abnormalities were discussed and refined leading to modifications. The current report summarizes the methods used during the consensus meeting and the outcomes achieved as pertains to the application of en face OCT for cRORA grading and simplification of the RPE assessment criteria.

main outcome measuresDefining the role of en face OCT in the detection and quantification of hyperTDs, improving classification of cRORA, and refining the terminology related to RPE alterations to enhance grading consistency.

resultsDuring the consensus case discussions, high levels of agreement were achieved for hyperTD detection using en face OCT. The CAM group affirmed the role of en face OCT as a critical adjunct to traditional B-scan analysis, for more precise measurement of the area of cRORA lesions and for distinguishing threshold cRORA from smaller incomplete retinal pigment epithelial and outer retinal atrophy lesions. Additionally, merger of RPE attenuation and RPE disruption into a unified category termed "abnormal RPE band" significantly reduced interreader variability, leading to greater consistency among graders.

conclusionsThe integration of en face OCT with cross sectional B-scan imaging enhances the accurate classification and area measurement of early atrophic alterations in age-related macular degeneration, improving diagnostic consistency and lesion assessment. The consensus panel's adoption of the abnormal RPE band term as a unified category for RPE abnormalities may reduce confusion regarding the definition of RPE degeneration and has the potential to improve interreader variability. FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any materials discussed in this article.

Indexed as

Fluorescein AngiographyRetinal Photoreceptor Cell Outer SegmentRetinal Pigment EpitheliumTomography, Optical CoherenceAtrophyFundus OculiHumansAge-related macular degenerationComplete retinal pigment epithelial and outer retinal atrophyEn faceIncomplete retinal pigment epithelial and outer retinal atrophyOCT

Identifiers

PMID41621805
PMCPMC13456394

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.