ArticleHIV medicine2026
Virological outcomes with Bictegravir/Emtricitabine/Tenofovir alafenamide (B/F/TAF) in people previously treated with darunavir-based antiretroviral therapy.
Article in HIV medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
backgroundDarunavir-based antiretroviral therapy (ART) is commonly used in people with HIV who experience adherence challenges and/or have complex resistance patterns. Changes in ART commissioning have led to an increased use of Bictegravir/Emtricitabine/Tenofovir alafenamide (B/F/TAF) in these populations despite limited real-world outcome data.
methodsSingle centre, retrospective analysis of virological outcomes in individuals previously treated with Darunavir who initiated B/F/TAF before 01/01/2025. Logistic regression was used to analyse associations with sustained virological suppression (HIV RNA <200 copies/mL) on B/F/TAF.
resultsOf the 223 individuals who initiated B/F/TAF, 207 (median age 52 [40-58] years, 38% female, 69% Black ethnicity, 24% with CD4 < 200 cells/mm
conclusionsSubstituting of Darunavir-based ART with B/F/TAF in this challenging population was associated with treatment-emergent INSTI and NRTI resistance. Historical resistance did not predict virological outcomes and treatment-emergent resistance did not preclude re-suppression on B/F/TAF, suggesting that adherence remains a major barrier to achieving long-term virological success.
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