Evidence map›Paper›PMID 41622222›Full record

ArticleJournal of nanobiotechnology2026

HIFU postoperative hypoxia-activated metal-organic frameworks modulate the tumor microenvironment to augment immunotherapy.

Chengyan Luo, Dezhou Wu, Song Peng, Siyi Xu, Dengke Zhang, Xinchang Huang, Weiji Qin, Hongyan Li, Huanan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chengyan Luo *Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
Dezhou Wu *Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
Song PengDepartment of Radiology, Women and Children's Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
Siyi XuDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
Dengke ZhangDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
Xinchang HuangDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
Weiji QinDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
Hongyan LiDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
Huanan LiDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China. 102733@cqmu.edu.cn.

Funding

National Natural Science Foundation of China 82272024Senior Medical Talents Program of Chongqing for Young and Middle-aged YXGD202472
6 · The paper itself

Abstract

Limited intensity and duration of high-intensity focused ultrasound (HIFU)-induced immune response largely hinder postoperative immunotherapy due to low immunogenicity and immunosuppression of tumor microenvironment (TME). In this study, effect-specific metal-organic frameworks (MOFs) were designed based on the severe hypoxia of postoperative tumors through regulating TME to enhance body's antitumor immune response. The combination of iron ions, hypoxic-activated prodrug banoxantrone, and indoleamine 2,3-dioxygenase (IDO) signaling pathway inhibitor NLG919 is utilized to construct MOFs loaded with CaCO

Indexed as

High-Intensity Focused Ultrasound AblationImmunotherapyMetal-Organic FrameworksTumor MicroenvironmentAnimalsCell Line, TumorHumansHypoxiaMiceMice, Inbred BALB CMetal-Organic FrameworksAntitumor immune responseHIFUHypoxia-activatedImmune microenvironmentMetal-organic frameworks

Identifiers

PMID41622222
PMCPMC12952089

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.