Evidence map›Paper›PMID 41622376›Full record

ArticleFunctional & integrative genomics2026

HSF4 alleviates ferroptosis in colorectal cancer through transcriptional regulation of MBOAT1/2.

Kelin Yue, Haolin Wu, Kexin Li, Shu Yang, Xuan Bai, Wenjing Zhang, Yu Zhang

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Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kelin Yue *Department of Gastroenterology, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, #157 Jinbi Rd, Kunming, Yunnan, 650032, China.
Haolin Wu *The Laboratory of Basic Pharmaceutical Research, The General Hospital of the People's Liberation Army (PLAGH), Beijing, China.
Kexin LiFaculty of Medicine, Kunming University of Science and Technology, Kunming, China.
Shu YangDepatment of Medical Oncology, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Xuan BaiDepartment of Gastroenterology, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, #157 Jinbi Rd, Kunming, Yunnan, 650032, China.
Wenjing ZhangDepatment of Medical Oncology, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China. wenjing_zhang1@163.com.
Yu ZhangDepartment of Gastroenterology, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, #157 Jinbi Rd, Kunming, Yunnan, 650032, China. yuzhang320@sina.com.

Funding

Joint Foundation of Kunming Medical University and Yunnan Provincial Science and Technology Department 202201AY070001-256National Natural Science Foundation of China 82260601National Natural Science Foundation of China 82360556Yunnan Medical Training Program 202205AC160070Yunnan Medical Training Program XDYC-YLWS-2024-0067
6 · The paper itself

Abstract

Heat shock factor (HSF) family proteins modulate ferroptosis in various tumors. We previously confirmed that HSF4 performs a carcinogenic role in colorectal cancer (CRC), but its function in ferroptosis remains unclear. Therefore, this study aims to reveal whether HSF4 regulates the ferroptosis process in CRC and its potential molecular mechanisms. This study found that HSF4 overexpression markedly attenuated Erastin-induced cell death and mitochondrial damage in HT29 and HCT116 cells. HSF4 effectively reduced lipid peroxidation and Fe

Indexed as

Colorectal NeoplasmsFerroptosisHeat Shock Transcription FactorsAmino Acid Transport System y+AnimalsCell Line, TumorCoenzyme A LigasesGene Expression Regulation, NeoplasticHCT116 CellsHT29 CellsHumansIronLipid PeroxidationLong-Chain-Fatty-Acid-CoA LigaseMicePhospholipid Hydroperoxide Glutathione PeroxidaseAmino Acid Transport System y+Coenzyme A LigaseserastinHeat Shock Transcription FactorsIronLong-Chain-Fatty-Acid-CoA LigasePhospholipid Hydroperoxide Glutathione PeroxidasePiperazinesSLC7A11 protein, humanColorectal cancerFerroptosisHSF4Lipid metabolismMBOAT1MBOAT2Transcriptional regulation

Identifiers

PMID41622376

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.