ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2025
Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The current study was conducted to assess the effect of grape seed extract (GSE) supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in migraine patients. Materials and Methods: In this randomized double-blinded controlled clinical trial, 50 patients with migraine were randomly allocated to receive either 200 mg/day GSE supplement ( Results: Based on the within-group comparison, patients in the GSE group had a significant reduction in severity, frequency and duration of migraine attacks, HDR, migraine disability, systolic blood pressure, and serum levels of CGRP. GSE group also had better scores in the migraine-specific quality of life questionnaire and mental health questionnaire. When we performed the analysis using the univariate analysis of variance, the effect of GSE on serum CGRP levels (-0.07 ± 0.03 in the GSE group vs. 0.07 ± 0.03 in the placebo group, Conclusion: This study provides evidence supporting the beneficial effects of GSE supplement on the serum levels of CGRP. Trial registration: IRCT20121216011763N56.
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