Evidence map›Paper›PMID 41623478›Full record

ArticleiScience2026

Thrombospondin 1 aggravates cardiac remodeling in heart failure with preserved ejection fraction by inhibiting mitophagy.

Xingpeng Bu, Shuo Sha, Zhenzhen Zhang, Sicheng Bian, Shuhui Feng, Chunxia Li, Lei Wang, Huanzhen Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. The Role of Thrombospondin-2 in Myocardial Fibrosis.Drug design, development and therapy · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xingpeng BuFirst Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Shuo ShaFirst Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Zhenzhen ZhangFirst Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Sicheng BianDepartment of Medicine, The MetroHealth System, Case Western Reserve University, Cleveland, Ohio, USA.
Shuhui FengFirst Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Chunxia LiDepartment of Geriatric Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
Lei WangDepartment of Geriatric Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
Huanzhen ChenDepartment of Cardiology, First Hospital of Shanxi Medical University, Taiyuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) accounts for over half of all heart failure cases, but its underlying mechanisms remain unclear. Mitochondrial dysfunction and defective mitophagy are increasingly recognized as central features of HFpEF. Thrombospondin 1 (Thbs1), a matricellular protein involved in cardiovascular remodeling, has not been explored in this context. Here, we show that

Indexed as

Cell biologyModel organismOmics

Identifiers

PMID41623478
PMCPMC12857411

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.