ReviewFrontiers in reproductive health2025
Hormonal regulation and reproductive improvement with adjunctive Zishen Yutai Pill in polycystic ovary syndrome: a systematic review with meta-analysis.
Review in Frontiers in reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To systematically evaluate the therapeutic efficacy and safety of Zishen Yutai Pill (ZYP) as an adjunctive treatment for women with polycystic ovary syndrome (PCOS) through systematic review and meta-analysis of randomized controlled trials. Materials and methods: A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines. Seven major databases, including PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP, and Wan Fang Database, were searched from inception through March 1, 2025. Randomized controlled trials comparing ZYP combined with Western medicines vs. Western medicines alone were included. Results: Eighteen randomized controlled trials encompassing 1,751 participants with PCOS met the inclusion criteria. Meta-analysis demonstrated that ZYP, when combined with Western medicines, produced statistically significant improvements compared with Western medicines alone. Combination therapy significantly enhanced pregnancy rates [relative risk [RR] = 1.52, 95% confidence interval [CI] = 1.35-1.76, Conclusion: This systematic review and meta-analysis suggests that adjunctive ZYP combined with Western medicines may improve reproductive outcomes in women with PCOS. However, the certainty of evidence for most outcomes was low or very low, and many trials had high or unclear risk of bias. Accordingly, these findings should be interpreted as hypothesis-supporting rather than practice-changing, and well-designed, independently funded multicenter randomized controlled trials with standardized outcome definitions are required before routine clinical use or guideline integration can be considered. Systematic Review Registration: PROSPERO CRD42024522660.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.