ArticleBioinformation2025
Assessment of lixisenatide-induced nephropathy in chick embryos: Implications for prevention of diabetic kidney disease.
Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and the direct renal effects of GLP-1 receptor agonists remain underexplored. Using a hyperglycemic chick embryo model (n=120), we evaluated dose-dependent nephroprotective effects of lixisenatide. Hyperglycemia induced renal hypertrophy, histological injury, oxidative stress, inflammation and apoptosis. Lixisenatide, particularly at high doses, significantly ameliorated these changes, normalizing kidney-to-body ratios and reducing MDA, TNF-α and caspase-3 activity. Thus, we show that lixisenatide directly preserves renal structure and function independent of systemic metabolic control.
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