Evidence map›Paper›PMID 41623902›Full record

ArticleJournal of the Endocrine Society2026

Acyl-CoA Synthetase 5 Knockout and Inhibitors Protect Against Diet-Induced Obesity in Mice by Activating the Ileal Brake.

David R Powell, Isaac Van Sligtenhorst, Alan Main, Haihong Jin, Kenneth G Carson, Zhi-Cai Shi, Jonathan Swaffield, Melinda Smith, Angela Harris, Suma Gopinathan and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

David R PowellLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.ORCID https://orcid.org/0000-0003-0656-0124
Isaac Van SligtenhorstLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Alan MainLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Haihong JinLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Kenneth G CarsonLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Zhi-Cai ShiLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Jonathan SwaffieldLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Melinda SmithLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Angela HarrisLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Suma GopinathanLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Kenneth A PlattLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Jeffrey WadeLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Brian ZambrowiczLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Patricia McDonaldLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Darren OrtonLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Lakshmi KuttippurathuLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Michael MullensLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Jennifer GreerLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Qi Melissa YangLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.
Zhi-Ming DingLexicon Pharmaceuticals, The Woodlands, TX 77381, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genes regulating body fat are shared by mice and humans, and mouse knockout phenotypes for known drug targets correlate well with drug efficacy, suggesting that mouse knockout phenotyping can identify anti-obesity drug targets. Mice with an intestine-specific

Indexed as

energy intakegene knockoutinhibitorinsulin sensitivityobesitysmall molecule

Identifiers

PMID41623902
PMCPMC12852994

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.