Evidence map›Paper›PMID 41623907›Full record

ArticleJournal of the Endocrine Society2026

Greater Concentrations of IGF Binding Protein-2 after Bariatric Surgery Compared with Diet.

Chino Aneke-Nash, Sarah Borden, Emily G Werth, Jamie Leskowitz, Rajasekhar Ramakrishnan, Jorge Arriaza Sagredo, Tirissa J Reid, Abraham Krikhely, Marc Bessler, Lewis M Brown and 1 more

Abstract read
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In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chino Aneke-NashDigestive and Liver Disease, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Sarah BordenEndocrinology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Emily G WerthQuantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Jamie LeskowitzEndocrinology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Rajasekhar RamakrishnanDepartment of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Jorge Arriaza SagredoEndocrinology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Tirissa J ReidEndocrinology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Abraham KrikhelyDepartment of Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Marc BesslerDepartment of Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Lewis M BrownQuantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Judith KornerEndocrinology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.ORCID https://orcid.org/0000-0001-5989-8001

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Bariatric surgery causes greater sustained weight loss (WL) and metabolic improvements compared to lifestyle modification. It remains unclear which metabolic changes are solely attributable to WL and which also involve WL-independent changes. Objective: The objective of this study was to quantify changes in the adiponectin/leptin ratio and IGF binding protein 2 (IGFBP-2), both markers of metabolic disease. Methods: Adults with body mass index ≥35 kg/m Results: The LCD and surgery groups had similar median WL of 15% at T2 ( Conclusion: IGFBP-2 levels and the adiponectin/leptin ratio improve after WL. The greater increase in IGFBP-2 levels after surgery compared with LCD may have long-term beneficial effects that appear to be partly independent of the degree of weight reduction.

Indexed as

adiponectinbariatric surgeryinsulin-like growth factor binding proteinleptinlow-calorie dietobesity

Identifiers

PMID41623907
PMCPMC12852998

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.