Association Between the Triglyceride-Glucose Index and Incident Chronic Severe Pain in Middle-Aged and Older Chinese Adults: A Nationwide Cohort Study.

Dizhou Zhao, Yuanyuan Cui, Hong Lu, Haoyi Yang, Weijie Guo, Zhiming Shan, Chaoran Wu

Abstract read

In one paragraph

Article in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dizhou ZhaoDepartment of Anesthesiology, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China, sustc.edu.cn.ORCID https://orcid.org/0009-0002-1305-3964

Yuanyuan CuiDepartment of Anesthesiology, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China, sustc.edu.cn.

Hong LuFunan Community Health Service Center, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China, sysu.edu.cn.

Haoyi YangDepartment of Anesthesiology, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China, sustc.edu.cn.

Weijie GuoDepartment of Anesthesiology, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China, sustc.edu.cn.

Zhiming ShanDepartment of Anesthesiology, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China, sustc.edu.cn.ORCID https://orcid.org/0000-0002-4575-3933

Chaoran WuDepartment of Anesthesiology, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China, sustc.edu.cn.ORCID https://orcid.org/0009-0003-5193-7813

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Insulin resistance (IR) has been linked to chronic severe pain (CSP) in previous studies. The triglyceride-glucose (TyG) index serves as an indicator of IR. However, whether TyG control level affects the further CSP incidence has not been well established. In this study, we aimed to identify the association between TyG control level and the risk of CSP. Methods: Participants with a continuous statement of severe pain in two consecutive waves of investigation from the China Health and Retirement Longitudinal Study were defined as CSP. The TyG control level was divided into four classes. The association between the baseline TyG and TyG control level CSP incidence was analyzed through logistic regression and restricted cubic spline analysis. Results: A total of 113 (3.18%) of 3546 participants were diagnosed as CSP within 9 years. The TyG index has a significant correlation with high CSP incidence (OR = 1.51 (95% CI, 1.16-1.96), Conclusions: The TyG index should be regarded as a simple indicator of CSP incidence. Continuous monitoring of the TyG index is more suitable for predicting CSP incident risk compared to a one-time TyG measurement, and long-term, well-controlled management of the TyG index may be an efficient approach to reduce the risk of CSP incidence.

Indexed as

Blood GlucoseChronic PainTriglyceridesAgedChinaCohort StudiesEast Asian PeopleFemaleHumansIncidenceInsulin ResistanceLongitudinal StudiesMaleMiddle AgedBlood GlucoseTriglyceridesCHARLSchronic severe paininsulin resistanceTyG index

Identifiers

PMID41623939

DOI10.1155/prm/2464060

PMCPMC12856695

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.