ReviewFrontiers in physiology2025
Resistance training and cardiovascular health: epigenetic regulation.
Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Skeletal muscle dysfunction induced by cancer immunotherapy: mechanistics insights and surgical implications.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance training plays a crucial role in cardiovascular health by promoting epigenetic adaptations that beneficially modulate gene expression. These modifications include DNA methylation, histone alterations, and regulation by non-coding RNAs, which directly affect cardiac muscle and the vascular system. Such epigenetic changes lead to improved cardiac function, reduced inflammation, optimized metabolism, and protection against cardiovascular diseases. Resistance training induces the release of signaling molecules that mediate favorable systemic adaptations. Studies demonstrate that resistance training, especially when combined with aerobic training, improves cardiovascular risk factors such as blood pressure and lipid profile. Epigenetic regulation is fundamental to the plasticity of the cardiovascular system and the reversibility of exercise-induced adaptations. Although extreme exercise may pose risks, regular and moderate resistance training is safe and effective in the prevention and management of cardiovascular diseases through these molecular mechanisms. Further investigation into these epigenetic modifications may unveil novel exercise-based therapeutic strategies to enhance cardiovascular health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.