Evidence map›Paper›PMID 41624060›Full record

ArticleHuman mutation2026

Disentangling Links Between Lung Cancer and Infectious Pneumonia via Real-World Data and Integrative Genomics.

Yi-Fei Diao, Zhe Chen, Yi-Fan Tang, Tian Xie, Qi-Yue Ge, Kai Xie, Zhuang-Zhuang Cong, Yi Shen, Shaoqiu Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yi-Fei DiaoDepartment of Cardiothoracic Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China, nju.edu.cn.ORCID https://orcid.org/0009-0007-4376-3621
Zhe ChenDepartment of Thoracic and Cardiovascular Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou Key Laboratory of Chest Disease Diagnosis and Treatment, Suzhou, China.ORCID https://orcid.org/0009-0005-1165-0839
Yi-Fan TangAcademy of Pharmacy, Xi'an Jiaotong-Liverpool University (XJTLU), Suzhou, China.ORCID https://orcid.org/0009-0008-5197-2543
Tian XieDepartment of Cardiothoracic Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China, nju.edu.cn.ORCID https://orcid.org/0009-0008-3406-0315
Qi-Yue GeDepartment of Cardiothoracic Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China, nju.edu.cn.ORCID https://orcid.org/0009-0000-7233-7014
Kai XieDepartment of Thoracic and Cardiovascular Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou Key Laboratory of Chest Disease Diagnosis and Treatment, Suzhou, China.ORCID https://orcid.org/0000-0003-4284-9646
Zhuang-Zhuang CongDepartment of Cardiothoracic Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China, nju.edu.cn.ORCID https://orcid.org/0009-0000-0437-6265
Yi ShenDepartment of Cardiothoracic Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China, nju.edu.cn.ORCID https://orcid.org/0009-0000-6656-5336
Shaoqiu ChenDepartment of Cardiothoracic Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China, nju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer (LC) patients frequently develop infectious pneumonia, often leading to suspension of anticancer therapy, yet the impact of LC on pneumonia progression remains unclear. This study employed a multidimensional approach to investigate whether LC constitutes a critical factor contributing to pulmonary infection onset and adverse short-term outcomes. Data from two intensive care unit databases were analyzed to assess the association between LC and pneumonia incidence and prognosis from a real-world perspective, with Mendelian randomization (MR) applied to validate causality. Additionally, post-GWAS analyses were conducted to explore comorbidity interaction patterns and potential shared therapeutic targets. Cross-sectional and cohort analyses identified LC as an independent risk factor for infectious pneumonia development and 28-day mortality, findings corroborated by sensitivity analyses across multiple models and datasets. Meta-analysis of MR results demonstrated causal relationships between genetically predicted LC and both pneumonia risk (OR = 1.103, 95% CI: 1.031-1.181,

Indexed as

GenomicsLung NeoplasmsPneumoniaComorbidityFemaleGenome-Wide Association StudyHumansMalePrognosisRisk FactorsCOPDlung cancerpneumoniaprognosis

Identifiers

PMID41624060
PMCPMC12859732

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.