ArticleFASEB bioAdvances2026
Oral Supplementation With a Bovine Thymus Extract Reduces Neuronal Excitability in Aging Mice.
Article in FASEB bioAdvances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Oral Supplementation With a Bovine Thymus Extract Reduces Neuronal Excitability in Aging Mice.FASEB bioAdvances · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system (CNS). Many aspects of GABAergic neurotransmission, including the densities of GABAergic neurons, the synthesis of GABA and its interaction with the respective receptors, are believed to be altered during aging, contributing to increased neuronal excitability seen in multiple neurodegenerative conditions, such as dementias, Alzheimer's disease, and traumatic brain injury (TBI). Oral administration of a nuclear fraction extract of the bovine thymus gland (thymus nuclear fraction-TNF) to rats was recently reported to improve their functional recovery from controlled cortical impact (CCI)-an animal model of TBI. Given that individual thymic peptides and mixed thymus fractions were also found to have broad neuroprotective effects and anti-neuroinflammatory activity, we sought to investigate the impact of TNF on GABAergic neurotransmission in the aging mouse brain. Using biochemical investigation, electrophysiological recordings, obtained using electroencephalography (EEG), and power spectral density analysis, we evaluated GABAergic protein expression and cortical neuronal activity in aged control mice and in mice supplemented with a low dose (LD) or a high dose of TNF for 14 weeks. We uncovered increased expression of two isoforms of glutamic acid decarboxylase, GAD65 and GAD67, and increased levels of β2/β3 subunits of GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.