Evidence map›Paper›PMID 41624488›Full record

ArticleJHEP reports : innovation in hepatology2026

Genome-wide association study identifies three PNPLA3/SAMM50 SNPs associated with HCC development in non-viral liver disease.

Xia-Rong Liu, Tsai-Hsuan Yang, Tung-Hung Su, Szu-Ching Yin, Yi-Ting Chen, Fen-Fang Chen, See-Tong Pang, Ming-Chih Hou, Yen-Chun Peng, Shun-Fa Yang and 11 more

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In one paragraph

Article in JHEP reports : innovation in hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Xia-Rong LiuInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Tsai-Hsuan YangInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Tung-Hung SuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Szu-Ching YinInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yi-Ting ChenInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Fen-Fang ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
See-Tong PangDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
Ming-Chih HouDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Yen-Chun PengDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Shun-Fa YangInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Peng-Ju HuangKaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.
Sing-Lian LeeDivision of Endocrinology, Department of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
Ming ChenDepartment of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.
Chih-Yang HuangCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Ya-Hsuan ChangInstitute of Molecular and Genomic Medicine, National Health Research Institute, Taiwan.
Hsuan-Yu ChenInstitute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Hwai-I YangGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Ming-Lung YuCollege of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chien-Jen ChenGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Jia-Horng KaoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Mei-Hsuan LeeInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Aims: Few genome-wide association studies have examined genetic variants associated with hepatocellular carcinoma (HCC) risk in individuals seronegative for HBsAg and anti-HCV, and the long-term impact of these variants remains uncertain. Methods: This multi-stage study analyzed adults >30 years old who were seronegative for HBsAg and anti-HCV. In the genome-wide association study discovery phase, 765 HCC cases and 9,949 controls were analyzed for 308,693 SNPs, with significant SNPs confirmed in community-based (171 HCC cases, 684 controls) and hospital-based (470 HCC cases, 5,460 controls) validation sets. A cohort of 67,909 participants, followed from 2012 to 2021, was used to evaluate the long-term HCC risk associated with these variants. Results: Ten SNPs in Conclusions: This study identified Impact and implications: Variants in the

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biobanklong-term riskprospective cohortSteatosissusceptibility

Identifiers

PMID41624488
PMCPMC12857342

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.