HOCl and viscosity dual-responsive fluorescent probe for accurate discrimination between early hepatocellular carcinoma and acute liver injury.

Jiakang Sun, Lidong Cao, Mengmeng Dong, Yumeng Liu, Yun Wang, Yong Zhan

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jiakang SunCollege of Life Sciences, China Jiliang University, Hangzhou, 310018, China.

Lidong CaoGeneral Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Mengmeng DongGeneral Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Yumeng LiuGeneral Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Yun WangCollege of Life Sciences, China Jiliang University, Hangzhou, 310018, China.

Yong ZhanCollege of Life Sciences, China Jiliang University, Hangzhou, 310018, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The accurate differentiation between early-stage hepatocellular carcinoma (HCC) and acute liver injury (ALI) remains a critical yet unresolved challenge in clinical practice, as these conditions share overlapping symptoms and biomarkers, often leading to misdiagnosis with conventional techniques. Although fluorescent probes offer potential for high-sensitivity imaging, existing designs typically detect only a single parameter and lack subcellular targeting precision. Consequently, a methodology that simultaneously visualizes multiple pathology-specific biomarkers within a key organelle for precise discrimination is urgently needed. Here, we present a lipid droplet-targeted, dual-channel fluorescent probe,

Indexed as

Acute liver injuryDisease diagnosisFluorescent probeHepatocellular carcinomaViscosity and HOCl

Identifiers

PMID41624541

DOI10.1016/j.mtbio.2026.102816

PMCPMC12858355

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.