ArticleThe Pan African medical journal2025
Burden, causes, and treatment approaches of recurrent pregnancy loss: a scoping review.
Article in The Pan African medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Immunoglobulins in recurrent pregnancy loss: Emerging biomarkers and therapeutic targets.Molecular biology reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent pregnancy loss (RPL), defined as the loss of two or more clinically recognized pregnancies before 20 weeks of gestation, poses a significant global medical challenge. Affecting up to 5% of couples trying to conceive, its multifactorial causes include genetic, anatomical, immunological, hormonal, and environmental factors. However, 65% of cases remain idiopathic, exacerbating the complexity of diagnosis and treatment. Low- and middle-income countries (LMICs) face additional challenges due to limited diagnostic capacities, socioeconomic disparities, and the burden of infectious diseases. Advancements in diagnostic and treatment technologies offer promise but are often inaccessible in resource-limited settings. This scoping review involved systematic searches in PubMed, Cochrane Library, and other sources for studies published since 2014. Eligible studies focused on the aetiology, diagnosis, and treatment of RPL. A total of 61 studies were included, primarily from high-income countries, with gaps noted in data from LMICs. Findings highlight RPL's multifaceted aetiology, including chromosomal abnormalities, uterine anomalies, thrombophilias, infections, and lifestyle factors. Advanced diagnostic methods such as next-generation sequencing enable personalized management but remain inaccessible in most LMICs. Management strategies range from immunotherapy and anticoagulants to surgical interventions and lifestyle modifications. Despite promising advancements, gaps in evidence and resource disparities persist, particularly in LMICs, where cultural stigmas and limited healthcare access further complicate care delivery. Addressing RPL requires a multidisciplinary approach encompassing diagnostics, treatment, and psychological support. Tailored strategies are essential for LMICs where inadequate healthcare infrastructure and socioeconomic barriers hinder progress. Prioritizing research, equitable access, and collaborative global efforts are vital to improving outcomes for affected couples worldwide.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.