Advances in cellular and molecular mechanisms of trauma-induced organ inflammation and dysfunction.

Jieyan Wang, Hui Liang, Jie Fan

Abstract readReview

In one paragraph

Review in Burns & trauma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Mature-StageInternational journal of molecular sciences · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jieyan WangDepartment of Urology, People's Hospital of Longhua, No. 38 Jinglong Jianshe Road, Shenzhen 518109, Guangdong, China.

Hui LiangDepartment of Urology, People's Hospital of Longhua, No. 38 Jinglong Jianshe Road, Shenzhen 518109, Guangdong, China.ORCID https://orcid.org/0000-0003-1460-8335

Jie FanDepartment of Surgery, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15213, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trauma represents a significant global health issue, often resulting in devastating and long-lasting effects on the body throughout a patient's life. Organ inflammation and dysfunction caused by trauma present additional challenges for clinicians. Therefore, understanding the cellular and molecular mechanisms of post-trauma systemic inflammation and organ dysfunction is essential for improving the management of trauma. This review aims to summarize current updates on the findings that explore different mechanisms of trauma-induced inflammation and organ dysfunction, highlighting the recent understanding of the vital roles of damage-associated molecular patterns, trauma-induced cell death, organ-organ cross-talk pathways, and the gut microbiota in the development and progression of post-traumatic systemic inflammation. We also discuss new approaches that can potentially guide further investigations of trauma diagnosis, treatment, and prognosis.

Indexed as

Abdominal and pelvic traumaDamage-associated molecular patternsExtremity traumaMolecular mechanismsThoracic traumaTramatic brain injuryTrauma-induced organ inflammation

Identifiers

PMID41624749

DOI10.1093/burnst/tkaf074

PMCPMC12860207

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.