ReviewFrontiers in immunology2025
Role of exosomes in gastrointestinal physiology and pathophysiology.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Bacterial Extracellular Vesicles in Aging: Mechanisms and Therapeutic Prospects.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Exosomes, which are molecular cargo-containing, nanosized extracellular vesicles formed through double invagination of the plasma membrane, have emerged as important mediators of intercellular communication within the gastrointestinal tract. In addition to its established function in digestion and nutrient uptake, the gastrointestinal tract is central to immune regulation and maintenance of epithelial barrier integrity. Exosomes derived from intestinal epithelial cells, the gut microbiota and gut resident immune cells are key in sustaining intestinal homeostasis and regulating host-microbiota interactions. Dysregulation of these vesicles is increasingly linked to gastrointestinal disease pathogenesis, including inflammatory bowel disease. Currently, exosomes are being explored for use as diagnostic biomarkers and therapeutic agents in gastrointestinal ailments. In this review, we examine the roles of exosomes in gastrointestinal health and disease, highlighting their contributions in the regulation of epithelial barrier function, modulation of immune responses and communication with the gut microbiota. We further discuss the dysregulation of exosome-mediated signaling pathways in IBD and assess their potential as next-generation therapies for gastrointestinal disorders.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.