Evidence map›Paper›PMID 41624877›Full record

ArticleFrontiers in immunology2025

Dual targeting of joint and lung disease: efficacy of tofacitinib plus iguratimod combination in progressive fibrosing rheumatoid arthritis-associated interstitial lung disease.

Yuan Zhu, Yingzi Ye, Wanlin Zhou, Xu Zheng, Weilin Xie, Zhiying Wu

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuan Zhu *Military Treatment Center, the 970th Hospital of the People's Liberation Army Joint Logistics Support Force, Yantai, China.
Yingzi Ye *Health Management Department, the Armed Police Yantai Special Service Sanatorium Center, Yantai, China.
Wanlin ZhouMilitary Treatment Center, the 970th Hospital of the People's Liberation Army Joint Logistics Support Force, Yantai, China.
Xu ZhengMilitary Treatment Center, the 970th Hospital of the People's Liberation Army Joint Logistics Support Force, Yantai, China.
Weilin XieMilitary Treatment Center, the 970th Hospital of the People's Liberation Army Joint Logistics Support Force, Yantai, China.
Zhiying WuMilitary Treatment Center, the 970th Hospital of the People's Liberation Army Joint Logistics Support Force, Yantai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the efficacy and safety of tofacitinib (TOF) plus iguratimod (IGU) in treating progressive fibrosing rheumatoid arthritis-associated interstitial lung disease (PF-RA ILD). Methods: This historical-controlled study enrolled 28 PF-RA ILD patients (13 received TOF plus IGU; 15 received the biologic/conventional synthetic disease-modifying anti-rheumatic drugs (b/csDMARDs). Disease activity, pulmonary function (PFTs), high-resolution computed tomography (HRCT) scores, and safety were assessed longitudinally and between groups. Results: Baseline characteristics were comparable ( Conclusion: TOF plus IGU demonstrated dual efficacy in controlling synovitis and lung fibrosis, with a favorable safety profile.

Indexed as

Antirheumatic AgentsArthritis, RheumatoidLung Diseases, InterstitialPiperidinesPyrimidinesSulfonamidesAgedChromonesC-Reactive ProteinDrug Therapy, CombinationFemaleHumansMaleMiddle AgedProtein Kinase InhibitorsTomography, X-Ray ComputedAntirheumatic AgentsChromonesC-Reactive ProteiniguratimodPiperidinesProtein Kinase InhibitorsPyrimidinesSulfonamidestofacitinibefficacyprogressive fibrosing interstitial lung diseaserheumatoid arthritistofacitinib plus iguratimodtreatment

Identifiers

PMID41624877
PMCPMC12855111

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.