Evidence mapPaperPMID 41625185Full record

ReviewImmunometabolism (Cobham, Surrey)2026

Developmental origins of immunometabolic health.

Yem J Alharithi, Gladys Smith, Alina Maloyan

Abstract readReview
In one paragraph

Review in Immunometabolism (Cobham, Surrey), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yem J AlharithiKnight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.
Gladys SmithUniversity of Pennsylvania, Philadelphia, PA, USA.
Alina MaloyanKnight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.

Funding

Mechanisms of airway hyperresponsiveness in the offspring of obese mothersR01HL164474 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$585k
Immunometabolic dysregulations in the offspring of obese mothersR21HD118370 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$234k
NHLBI NIH HHS R01 HL164474NICHD NIH HHS R21 HD099367NICHD NIH HHS R21 HD118370
6 · The paper itself

Abstract

Obesity during pregnancy not only affects maternal health but also puts offspring at high risk of obesity and of metabolic and cardiovascular diseases later in life, often regardless of their own lifestyle choices. This process, known as developmental programming, is increasingly being recognized as a critical factor shaping long-term health outcomes. In addition, a growing body of research highlights the importance of immunometabolism, the metabolism of immune cells, in the pathogenesis of obesity, metabolic disorders, cardiovascular disease, and cancer. Although the effects of maternal obesity on offspring health have been well documented in both epidemiological studies and preclinical models, its influence on the developing immune system and immunometabolic pathways is only beginning to be revealed. In this review, we explore the metabolic and inflammatory dimensions of developmental programming and discuss how an adverse maternal environment may shape the offspring's immunometabolic landscape.

Indexed as

developmental programmingdipeptidyl peptidase 4DOHADimmunometabolisminflammationmaternal obesitypregnancy

Identifiers

PMID41625185
PMCPMC12858031

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.