Evidence map›Paper›PMID 41625341›Full record

Trial reportIranian journal of medical sciences2026

Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial.

Farshad Gholipour, Davoud Gharakhani, Amirhossein Rahavian, Mahdi Norouzi, Mohammadreza Hajian, Serajoddin Vahidi, Mohammad Javad Nazarpour, Farbod Khorrami

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Iranian journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Farshad GholipourIsfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Davoud GharakhaniDepartment of Surgery, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Amirhossein RahavianAndrology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mahdi NorouziSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammadreza HajianNikan Research Institute, Isfahan, Iran.
Serajoddin VahidiDepartment of Surgery, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Mohammad Javad NazarpourIsfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Farbod KhorramiDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Idiopathic oligoasthenoteratozoospermia (iOAT) treatment still poses significant challenges. This study aims to compare the therapeutic efficacy of probiotics on sperm parameters of iOAT patients with placebo and antioxidants. Methods: In this triple-blind, randomized controlled trial, 110 men with iOAT were assigned to receive either a probiotic (Familact Results: Overall, 110 men (mean age of 34.3±4.5 years) were included in the final analysis. Significant Time×Group interactions were found for sperm concentration (P=0.003), motility (P<0.001), and morphology (P<0.001), but not for semen volume (P=0.71). After 3 months, the probiotic group showed significantly greater improvements in sperm concentration (10.42±1.11×10 Conclusion: This study is the first to directly compare probiotics and antioxidants in treating iOAT. Probiotics showed superior performance in sperm motility and morphology compared to antioxidants, although drawing a strong conclusion requires further robust studies

Indexed as

AntioxidantsAsthenozoospermiaOligospermiaProbioticsAdultHumansIranMaleSemen AnalysisSperm CountSperm MotilityAntioxidantsAndrologyAntioxidantsMale infertilityOligospermiaProbiotics

Identifiers

PMID41625341
PMCPMC12858446

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.