Evidence map›Paper›PMID 41625354›Full record

ArticleOphthalmology science2026

Automated Feature Segmentation of Ultra-Widefield OCT Images.

John D Jackson, Mani K Woodward, David A Sutter, Aaron S Coyner, Carol X Wang, Susan R Ostmo, Michael F Chiang, Yali Jia, David Huang, Yifan Jian and 2 more

Abstract read
In one paragraph

Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

John D JacksonCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Mani K WoodwardCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
David A SutterCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Aaron S CoynerCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Carol X WangJesuit High School, Portland, Oregon.
Susan R OstmoCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Michael F ChiangNational Eye Institute, National Institutes of Health, Bethesda, Maryland.
Yali JiaCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
David HuangCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Yifan JianCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
J Peter CampbellCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Benjamin K YoungCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI John Peter Campbell · 1995 to 2026
$19.4M
OCT Angiography for Neovascular Age-related Macular DegenerationR01EY024544 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Steven T Bailey, Yali Jia · 2014 to 2026
$6.2M
OCTA Precursors of Vision-Threatening Complications of Diabetic RetinopathyR01EY035410 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Thomas Hwang, Yali Jia · 2023 to 2026
$2.5M
Translational Vision Science Research at Oregon Health & Science UniversityT32EY023211 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Yali Jia, Kate E Keller · 2013 to 2026
$2.4M
Advancing visible-light OCT in oxygen-induced retinopathyR01EY036429 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI John Peter Campbell, Yali Jia · 2024 to 2026
$2.0M
Wide-field and projection-resolved optical coherence tomography angiography in diabetic retinopathyR01EY027833 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HWANG, THOMAS, JIA, YALI · 2017 to 2020
$1.8M
A diagnostic platform for diabetic retinopathy based on OCT angiography and artificial intelligenceR43EY036781 · NEI · IFOCUS IMAGING LLC · PI HORMEL, TRISTAN, JIA, YALI · 2024 to 2024
$306k
NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY024544NEI NIH HHS R01 EY027833NEI NIH HHS R01 EY035410NEI NIH HHS R01 EY036429NEI NIH HHS R43 EY036781NEI NIH HHS T32 EY023211
6 · The paper itself

Abstract

Objective or Purpose: To develop a lightweight neural network for automated cross-sectional and en face segmentation of ultra-widefield (UWF) OCT images acquired for retinopathy of prematurity screening. Design: Cross-sectional study. Subjects: Twenty-five infants with a birth weight <1500 g or gestational age <31 weeks were scanned using a portable, handheld, swept-source UWF-OCT device. Methods Intervention or Testing: For cross-sectional B-scans, 3040 B-scans from 5 OCT volumetric scans obtained from 5 patients were segmented by 2 graders for the choroid and retina using custom-built tools in the Napari image viewer. Using these segmentations, a u-net with an EfficientNet-B0 backbone was trained in combination with task-specific augmentations to perform automated segmentation of the retina and choroid data with varying levels of image processing applied. For en face scans, 40 en face images from 20 unique patients were manually segmented by a single grader for retinal vessels. Using these segmentations, a u-net with an EfficientNet-B0 backbone was trained. Validation for both B-scans and en face images was performed using fivefold cross-validation. The fivefold cross-validation metrics were then compared with the metrics obtained by comparing grader segmentations. Main Outcome Measures: The Dice similarity coefficient (DSC) was used to assess B-scan and en face segmentations. Results: The retinal and choroidal b-scan segmentations produced a DSC ± standard deviation of 0.925 ± 0.021 and 0.797 ± 0.062, respectively, averaged across the fivefolds. The en face vasculature segmentation produced a DSC ± standard deviation of 0.625 ± 0.0450. Conclusions: Using u-net convolutional neural networks trained with task-specific augmentations, we developed en face and cross-sectional segmentations for UWF-OCT images, which will facilitate automated quantitative analysis with this novel modality. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Image processingMachine learningOCTRetinopathy of prematurity

Identifiers

PMID41625354
PMCPMC12858344

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.