ArticleJournal of aging research2026
Cellular Senescence in the Ascending Aorta and Complexity of Coronary Atherosclerosis.
Article in Journal of aging research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Integrin-Linked Kinase Plays an Active Role in the Regulation of Endothelial Senescence.Cells · 2026Article
- Cellular Senescence in the Ascending Aorta and Complexity of Coronary Atherosclerosis.Journal of aging research · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cellular senescence might have a key role in the pathogenesis of vascular aging and atherosclerosis. However, human data directly linking cellular senescence in the vascular tissue with coronary artery disease (CAD) are limited. This study aimed to investigate the relationship between the proportion of senescent cells in the ascending aorta and the complexity of CAD in patients undergoing coronary artery bypass grafting (CABG). Methods: Ascending aortic tissue samples were obtained from 112 patients during elective or urgent CABG surgery. Expressions of p16, p21, and β-galactosidase (β-gal) were evaluated as cellular senescence biomarkers using immunohistochemical analysis. The complexity of coronary lesions was quantified by the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score. Patients were stratified into low and moderate-to-high SYNTAX score groups, and biomarker expression levels were compared between these subgroups. Results: The proportion of p16-positive cells in the ascending aorta was significantly higher in patients with moderate-to-high SYNTAX scores, by both percentage ( Conclusion: Increased expression of p16 and p21 in ascending aortic tissue is significantly associated with higher coronary atherosclerosis complexity in patients undergoing CABG. Among these biomarkers, p16 serves as an independent predictor of complex CAD, highlighting its potential role in vascular aging and atherosclerosis progression.
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Registered trials
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