SynthesisFrontiers in medicine2025
Metformin use in gestational diabetes mellitus and neonatal outcomes: a systematic review and meta-analysis on the risk of small for gestational age.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: It remains unclear whether maternal metformin use in gestational diabetes mellitus (GDM) is associated with an increased risk of small-for-gestational-age (SGA) newborns. Methods and results: A systematic literature search was conducted across PubMed, Embase, and the Cochrane Library up to September 1, 2024. Nineteen studies ( Conclusions: Maternal metformin use in the management of GDM doesn't increase SGA risk in offspring, suggesting its relative safety and effectiveness in this context. Further research is required to explore metformin's long-term effects of metformin on offspring of mothers with GDM. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251141984, identifier CRD420251141984.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.