ArticleFrontiers in neurology2025
White matter microstructural damage and its effect on cognitive impairment in patients with metabolic syndrome and cerebral small vessel disease.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Metabolic syndrome (MetS) is linked to cerebral small vessel disease (CSVD) and cognitive impairment in the elderly, but the underlying mechanisms remain unclear. This study investigated whether white matter (WM) microstructural damage mediates the relationship between CSVD severity and cognitive function in patients with MetS. Methods: A total of 170 right-handed participants aged 50-80 years were recruited, including 75 with MetS and 95 healthy controls (HC). MetS participants were divided into MetS without CSVD (MetS-NCSVD, Results: The MetS-CSVD group had significantly lower FA and higher MD in core WM fiber tracts compared to MetS-NCSVD and HC groups ( Conclusions: Our findings suggest that WM microstructural damage may account for the association between CSVD and cognitive impairment, acting as a potential mediator in MetS patients. Future longitudinal studies are needed to validate these findings and explore causal mechanisms.
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