ArticlePaediatrics & child health2025
Pain management strategies for peripheral arterial puncture/cannulation in neonates: A systematic review and meta-analysis.
Article in Paediatrics & child health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tipping the scale to no pain: Knowledge synthesis of procedural pain management in neonates.Paediatrics & child health · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Arterial puncture/cannulation is considered to be a severely painful procedure. Both non-pharmacological and pharmacological interventions are recommended by professional organizations to alleviate pain in neonates undergoing arterial puncture/cannulation, but these recommendations are not based on systematic review of the literature. The primary objective of this systematic review and meta-analysis was to synthesize the literature on pain management strategies in this setting. Methods: Databases were searched for randomized trials evaluating pharmacological and non-pharmacological interventions for pain mitigation for arterial puncture/cannulation from inception to July 2024. The literature search was updated in June 2025 and no additional eligible articles were identified for inclusion. Title and abstract screening, full-text screening, and data extraction were performed in duplicate. The risk of bias was assessed using Cochrane's risk of bias (RoB) 2.0 tool. The critically important outcome was pain measured using validated tools including unidimensional behaviour and multidimensional (comprising combinations of contextual, behavioural, and/or physiological components) tools. Secondary outcomes included procedure success and adverse events. Pooled effect estimates were standardized mean difference (SMD) and relative risk (RR) with 95% confidence intervals (CI) using random effects models. A GRADE assessment of the overall certainty of the evidence for each outcome was completed. Results: Five studies including a total of 358 neonates were included. All assessed pain from arterial puncture rather than cannulation. The interventions evaluated in the included studies were: 1) white noise (50 dB) compared to control (0 dB), 2) expressed breast milk compared to 25% oral dextrose, 3) music, 25% oral dextrose or both, 4) familiar scent compared to unfamiliar scent or control, and 5) 24% oral sucrose compared to no intervention. Expressed breast milk was effective in reducing procedural pain compared to 25% oral dextrose (SMD -0.95 [95% CI -1.64, -0.24];
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.