Evidence map›Paper›PMID 41626432›Full record

ArticleACS omega2026

Antimalarial Potential of Heme-Targeting Dimeric Compounds: Binding Efficacy vs. Membrane Retention Effects.

Victor Matheus Kemmer, Fabricio Santos, Fernanda Alice de Oliveira, Ana Claudia de Sousa Pinto, Amanda Luisa da Fonseca, Letícia Aparecida da Silva, Helen Gonçalves Marques, Fabio Vieira Dos Santos, Cleber Paulo Andrada Anconi, Franco Henrique Andrade Leite and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Victor Matheus KemmerDepartamento de Química, Universidade Estadual de Londrina, Londrina 86057-970, Brazil.
Fabricio SantosDepartamento de Química, Universidade Estadual de Londrina, Londrina 86057-970, Brazil.
Fernanda Alice de OliveiraNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.
Ana Claudia de Sousa PintoNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.
Amanda Luisa da FonsecaNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.
Letícia Aparecida da SilvaNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.
Helen Gonçalves MarquesNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.
Fabio Vieira Dos SantosNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.
Cleber Paulo Andrada AnconiDepartamento de Química, Instituto de Ciências Naturais, Universidade Federal de Lavras, Lavras 37200-900, Brazil.
Franco Henrique Andrade LeiteLaboratório de Químioinformática e Avaliação Biológica, Universidade Estadual de Feira de Santana, Feira de Santana 44036-900, Brazil.ORCID https://orcid.org/0000-0003-3166-6051
David Bacelar CostaLaboratório de Químioinformática e Avaliação Biológica, Universidade Estadual de Feira de Santana, Feira de Santana 44036-900, Brazil.
Fernando de Pilla VarottiNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.
Clébio Soares NascimentoNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.ORCID https://orcid.org/0000-0002-2444-2554
Luciana GuimarãesNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.ORCID https://orcid.org/0000-0002-6341-1718
Gustavo Henrique Ribeiro VianaNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.ORCID https://orcid.org/0000-0002-1521-7486
Renato Márcio Ribeiro-VianaNúcleo de Pesquisa em Química Biológica (NQBio), Universidade Federal de São João del Rei, Divinópolis 35501-296, Brazil.
Anna Paola ButeraDepartamento de Química, Universidade Estadual de Londrina, Londrina 86057-970, Brazil.ORCID https://orcid.org/0000-0002-8073-3970

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria, caused by Plasmodium parasites, remains a major global health burden with high morbidity and mortality rates. Despite the availability of treatments, the therapeutic arsenal is limited, and drug resistance poses a significant challenge. Thus, discovering new antimalarial compounds is critical, and understanding their mechanisms of action is key. One well-studied target is the heme group, which plays a central role in the degradation of the parasite's hemoglobin and infection success. This study describes the dimerization of 3-alkylpyridine derivatives, a class of compounds known to interact with heme, with the aim of enhancing their antimalarial activity. The dimers were analyzed for heme-binding affinity via UV-vis spectroscopy (

Identifiers

PMID41626432
PMCPMC12854372

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.